Trial reportCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010
Randomized controlled trial of a psychosocial telephone counseling intervention in BRCA1 and BRCA2 mutation carriers.
Trial report in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Assessing Psychological Morbidity in Cancer-UnaffectedCurrent oncology (Toronto, Ont.) · 2023Pooled it
- A Systematic Review of Randomized Controlled Trials to Assess Outcomes of Genetic Counseling.Journal of genetic counseling · 2017Pooled it
- Psychosocial telephone counseling for survivors of cervical cancer: results of a randomized biobehavioral trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Trial
- Intervention completion rates among African Americans in a randomized effectiveness trial for diet and physical activity changes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Trial
- Randomized controlled trial to test a computerized psychosocial cancer assessment and referral program: methods and research design.Contemporary clinical trials · 2013Trial
- Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2012Trial
- Equity in Genomic Medicine.Annual review of genomics and human genetics · 2022Review
- Psychosocial Interventions for Women with aCancers · 2021Article
- A review and definition of 'usual care' in genetic counseling trials to standardize use in research.Journal of genetic counseling · 2021Review
- Psychometric Properties of the MICRA Questionnaire in Portuguese Individuals Carrying SDHx Mutations.Journal of cancer education : the official journal of the American Association for Cancer Education · 2020Article
- Information and support needs of young women regarding breast cancer risk and genetic testing: adapting effective interventions for a novel population.Familial cancer · 2018Article
- Preferences for multigene panel testing for hereditary breast cancer risk among ethnically diverse BRCA-uninformative families.Journal of community genetics · 2018Article
- Cancer Predisposition Cascade Screening for Hereditary Breast/Ovarian Cancer and Lynch Syndromes in Switzerland: Study Protocol.JMIR research protocols · 2017Article
- Factors Associated with Interest in Gene-Panel Testing and Risk Communication Preferences in Women from BRCA1/2 Negative Families.Journal of genetic counseling · 2017Article
- Understanding the Needs of Young Women Regarding Breast Cancer Risk Assessment and Genetic Testing: Convergence and Divergence among Patient-Counselor Perceptions and the Promise of Peer Support.Healthcare (Basel, Switzerland) · 2016Article
- Seeking balance: decision support needs of women without cancer and a deleterious BRCA1 or BRCA2 mutation.Journal of genetic counseling · 2014Article
- Long-term satisfaction and quality of life following risk reducing surgery in BRCA1/2 mutation carriers.Hereditary cancer in clinical practice · 2014Article
- Communication of genetic test results to family and health-care providers following disclosure of research results.Genetics in medicine : official journal of the American College of Medical Genetics · 2014Article
- Communication and technology in genetic counseling for familial cancer.Clinical genetics · 2014Review
- Identification of genetic counseling service delivery models in practice: a report from the NSGC Service Delivery Model Task Force.Journal of genetic counseling · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundResponses following BRCA1/2 genetic testing are relevant for the comprehension of risk status and may play a role in risk management decision making. The objective of this study was to evaluate a psychosocial telephone counseling (PTC) intervention delivered to BRCA1/2 mutation carriers following standard genetic counseling (SGC). We examined the effect of the intervention on distress and the concerns related to genetic testing.
methodsThis prospective randomized clinical trial included 90 BRCA1/2 mutation carriers. We measured anxiety, depression, and genetic testing distress outcomes at intervention baseline and 6 and 12 months following disclosure. We evaluated the effects of SGC versus SGC plus PTC on psychological outcomes using intention-to-treat analyses through generalized estimating equations.
resultsAt 6 months, PTC reduced depressive symptoms (Z = -2.25, P = 0.02) and genetic testing distress (Z = 2.18, P = 0.02) compared with SGC. Furthermore, women in the intervention condition reported less clinically significant anxiety at 6 months (chi(2)(1) = 4.11, P = 0.04) than women who received SGC. We found no differences in outcomes between the intervention groups at the 12-month follow-up.
conclusionsAs an adjunct to SGC, PTC delivered following disclosure of positive BRCA1/2 test results seems to offer modest short-term benefits for distress and anxiety. These results build upon a growing literature of psychosocial interventions for BRCA1/2 carriers and, given the potential impact of affect on risk management decision making, suggest that some carriers may derive benefits from adjuncts to traditional genetic counseling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.