ReviewJournal of leukocyte biology2010
Leukocyte function in the aging immune system.
Review in Journal of leukocyte biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.
- Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2016Pooled it
- Respiratory virus immune response in the aged host.Immunity & ageing : I & A · 2026Review
- Collecting the evidence: mechanistic insights intoFrontiers in immunology · 2025Review
- Handgrip strength as a potential indicator of aging: insights from its association with aging-related laboratory parameters.Frontiers in medicine · 2025Article
- Article
- Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging.Seminars in immunology · 2023Review
- Article
- The Role of B Lymphocyte Subsets in Adipose Tissue Development, Metabolism, and Aging.Comprehensive Physiology · 2022Article
- The Influence of Heterochronic Non-Myeloablative Bone Marrow Transplantation on the Immune System, Frailty, General Health, and Longevity of Aged Murine Recipients.Biomolecules · 2022Article
- Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review.Frontiers in aging neuroscience · 2022Review
- The effects of aging on host resistance and disease tolerance to SARS-CoV-2 infection.The FEBS journal · 2021Review
- Immunity to acute virus infections with advanced age.Current opinion in virology · 2021Review
- Molecular Mechanisms of Immunosenescene and Inflammaging: Relevance to the Immunopathogenesis and Treatment of Multiple Sclerosis.Frontiers in neurology · 2021Review
- Hematological patterns and histopathological assessment of Miniature Pigs in the experiments on human mesenchymal stem cell transplantation.International journal of medical sciences · 2021Article
- Diclofenac-induced cytotoxicity in cultured carp leukocytes.Physiological research · 2020Article
- p16 a biomarker of aging and tolerance for cancer therapy.Translational cancer research · 2020Review
- Article
- Emerging Concepts and Technologies in Vaccine Development.Frontiers in immunology · 2020Review
- Contribution of Aging, Obesity, and Microbiota on Tumor Immunotherapy Efficacy and Toxicity.International journal of molecular sciences · 2019Review
- Response kinetics reveal novel features of ageing in murine T cells.Scientific reports · 2019Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aging is associated with a progressive dysregulation of immune responses. Whether these changes are solely responsible for the observed increased mortality and morbidity amongst the elderly is uncertain. Recent advances have highlighted the age-associated changes that occur beyond T and B lymphocytes. Additionally, multiple human and animal studies have identified a relationship between chronic low-grade inflammation and geriatric syndromes, such as frailty, suggesting that the phenomenon of "inflamm-aging" may provide a rationale for the increased vulnerability to chronic inflammatory diseases in older adults. In the present review, we broadly summarize our current understanding of age-dependent changes in leukocyte function and their contribution to aging-related disease processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.