ArticleBlood2010
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.
Article in Blood, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Meta-analysis of treatment with rabbit and horse antithymocyte globulin for aplastic anemia.International journal of hematology · 2017Pooled it
- IL-33/ST2 signaling in ILC2s drives exhaustion and myeloid skewing of HSCs in response to hematopoietic stress and aging.iScience · 2025Article
- Checkpoint Inhibitors in Acute Myeloid Leukemia.Biomedicines · 2023Review
- Article
- How Does Lifestyle Affect Hematopoiesis and the Bone Marrow Microenvironment?Toxicologic pathology · 2022Review
- Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.Cell stem cell · 2022Article
- Regulatory T cells promote the stemness of leukemia stem cells through IL10 cytokine-related signaling pathway.Leukemia · 2022Article
- Regulation of hematopoietic and leukemia stem cells by regulatory T cells.Frontiers in immunology · 2022Review
- Niches for Hematopoietic Stem Cells and Their Progeny.Immunity · 2018Review
- Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression.Scientific reports · 2018Article
- Microbe-Induced Inflammatory Signals Triggering Acquired Bone Marrow Failure Syndromes.Frontiers in immunology · 2017Review
- A Century of Radiation Therapy and Adaptive Immunity.Frontiers in immunology · 2017Review
- Niche heterogeneity in the bone marrow.Annals of the New York Academy of Sciences · 2016Review
- A T Cell View of the Bone Marrow.Frontiers in immunology · 2016Article
- Immunological Basis of Bone Marrow Failure after Allogeneic Hematopoietic Stem Cell Transplantation.Frontiers in immunology · 2016Review
- [Crosstalk between hematopoietic stem cells and immune system].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2015Article
- Regulation of hematopoietic and leukemic stem cells by the immune system.Cell death and differentiation · 2015Review
- Article
- Article
- Regulators help new immigrants settle down?Blood · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) possess the capacity to modulate both adaptive and innate immune responses. We hypothesized that Tregs could regulate hematopoiesis based on cytokine effector molecules they can produce. The studies here demonstrate that Tregs can affect the differentiation of myeloid progenitor cells. In vitro findings demonstrated the ability of Tregs to inhibit the differentiation of interleukin-3 (IL-3)/stem cell factor (colony-forming unit [CFU]-IL3)-driven progenitor cells. Inhibitory effects were mediated by a pathway requiring cell-cell contact, major histocompatibility complex class II expression on marrow cells, and transforming growth factor-beta. Importantly, depletion of Tregs in situ resulted in enhanced CFU-IL3 levels after bone marrow transplantation. Cotransplantation of CD4(+)FoxP3(+)(gfp) Tregs together with bone marrow was found to diminish CFU-IL3 responses after transplantation. To address the consequence of transplanted Tregs on differentiated progeny from these CFU 2 weeks after hematopoietic stem cell transplantation, peripheral blood complete blood counts were performed and examined for polymorphonuclear leukocyte content. Recipients of cotransplanted Tregs exhibited diminished neutrophil counts. Together, these findings illustrate that both recipient and donor Tregs can influence hematopoietic progenitor cell activity after transplantation and that these cells can alter responses outside the adaptive and innate immune systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.