ArticleJournal of clinical microbiology2010
Association of recurrent furunculosis with Panton-Valentine leukocidin and the genetic background of Staphylococcus aureus.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2013Pooled it
- Characterization of infecting strains and superantigen-neutralizing antibodies in Staphylococcus aureus bacteremia.Clinical and vaccine immunology : CVI · 2011Trial
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- Phenotypic and Genotypic Characterization ofPathogens (Basel, Switzerland) · 2025Article
- Characterisation ofToxins · 2025Article
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- Phenome-wide association study identifies new clinical phenotypes associated with Staphylococcus aureus infections.PloS one · 2024Article
- Clinical Impact ofAntibiotics (Basel, Switzerland) · 2023Review
- Characterisation of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Nasal vestibular furunculosis: Summarised case series.World journal of otorhinolaryngology - head and neck surgery · 2022Review
- Clonal Diversity, Antimicrobial Susceptibility and Presence of Genes Encoding Virulence Factors in Staphylococcus aureus Strains Isolated from Cut Wound Infections.Current microbiology · 2022Article
- Lateral Flow Immunoassay for the Detection of Panton-Valentine Leukocidin inFrontiers in cellular and infection microbiology · 2021Article
- Article
- Deciphering the Pathological Role of Staphylococcal α-Toxin and Panton-Valentine Leukocidin Using a NovelFrontiers in immunology · 2018Article
- Emergence and spread of worldwideInfection and drug resistance · 2018Article
- Molecular Epidemiology of Staphylococcus aureus in the General Population in Northeast Germany: Results of the Study of Health in Pomerania (SHIP-TREND-0).Journal of clinical microbiology · 2016Article
- Impact of cold atmospheric pressure argon plasma on antibiotic sensitivity of methicillin-resistant Staphylococcus aureus strains in vitro.GMS hygiene and infection control · 2016Article
- Outbreak of Panton-Valentine Leukocidin-Associated Methicillin-Susceptible Staphylococcus aureus Infection in a Rugby Team, France, 2010-2011.Emerging infectious diseases · 2016Article
- Eruptive furunculosis following the soak and smear regimen.BMJ case reports · 2015Article
- Epidemiological, clinical, outcome and antibiotic susceptibility differences between PVL positive and PVL negative Staphylococcus aureus infections in Western Australia: a case control study.BMC infectious diseases · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is a major cause of skin and soft tissue infections, such as furuncles, carbuncles, and abscesses, but it also frequently colonizes the human skin and mucosa without causing clinical symptoms. Panton-Valentine leukocidin (PVL) is a pore-forming toxin that has been associated with soft tissue infections and necrotizing pneumonia. We have compared the genotypes, virulence gene repertoires, and phage patterns of 74 furunculosis isolates with those of 108 control strains from healthy nasal carriers. The large majority of furunculosis strains were methicillin sensitive. Clonal cluster (CC) 121 (CC121) and CC22 accounted for 70% of the furunculosis strains but for only 8% of the nasal isolates. The PVL-encoding genes luk-PV were detected in 85% of furunculosis strains, while their prevalence among colonizing S. aureus strains was below 1%. luk-PV genes were distributed over several lineages (CCs 5, 8, 22, 30, and 121 and sequence type 59). Even within the same lineages, luk-PV-positive phages characterized furunculosis strains, while their luk-PV-negative variants were frequent among nasal strains. The very tight epidemiological linkage between luk-PV and furunculosis, which could be separated from the genetic background of the S. aureus strain as well as from the gene makeup of the luk-PV-transducing phage, lends support to the notion of an important role for PVL in human furunculosis. These results make a case for the determination of luk-PV in recurrent soft tissue infections with methicillin-sensitive as well as methicillin-resistant S. aureus.
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Registered trials
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