ArticleToxicological sciences : an official journal of the Society of Toxicology2010
Nickel sulfate induces location-dependent atrophy of mouse olfactory epithelium: protective and proliferative role of purinergic receptor activation.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- FAK inhibition following acute olfactory epithelial inflammation promotes neurogenesis and functional recovery through stem cell CNTF.Stem cells (Dayton, Ohio) · 2026Article
- Stem cell CNTF promotes olfactory epithelial neuroregeneration and functional recovery following injury.Stem cells (Dayton, Ohio) · 2025Article
- Characterization of pathological changes in the olfactory system of mice exposed to methylmercury.Archives of toxicology · 2024Article
- Constitutive and evoked release of ATP in adult mouse olfactory epithelium.Open life sciences · 2024Article
- Perinatal Exposure to Trace Elements: The Dubious Culprit of Autistic Spectrum Disorder in Children.Current pediatric reviews · 2024Review
- Nickel and aluminium mixture elicit memory impairment by activation of oxidative stress, COX-2, and diminution of AChE, BDNF and NGF levels in cerebral cortex and hippocampus of male albino rats.Current research in toxicology · 2023Article
- Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms.Trends in neurosciences · 2023Review
- SARS-CoV-2 infection of sustentacular cells disrupts olfactory signaling pathways.JCI insight · 2022Article
- Review
- Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
- Intrahippocampal Effects of Nickel Injection on the Affective and Cognitive Response in Wistar Rat: Potential Role of Oxidative Stress.Biological trace element research · 2021Article
- Chemosensory Dysfunction in Patients with COVID-19: What Do We Learn from the Global Outbreak?Current allergy and asthma reports · 2021Review
- SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain.iScience · 2020Article
- Inhibition of focal adhesion kinase increases adult olfactory stem cell self-renewal and neuroregeneration through ciliary neurotrophic factor.Stem cell research · 2020Article
- Neuromechanisms of SARS-CoV-2: A Review.Frontiers in neuroanatomy · 2020Review
- TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium.The Journal of general physiology · 2019Article
- Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway.Brain sciences · 2018Article
- Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals.Journal of occupational medicine and toxicology (London, England) · 2018Review
- Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice.eLife · 2017Article
- Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to nickel sulfate (NiSO(4)) leads to impaired olfaction and anosmia through an unknown mechanism. We tested the hypothesis that ATP is released following NiSO4-induced injury and that ATP promotes regenerative cell proliferation in the olfactory epithelium (OE). Male Swiss Webster mice were intranasally instilled with NiSO(4) or saline followed by ATP, purinergic receptor antagonists, or saline. We assessed the olfactory epithelium for NiSO(4)-induced changes using histology and immunohistochemistry 1-7 days postinstillation and compared results to olfactory bulb ablation-induced toxicity. Intranasal instillation of NiSO(4) produced a dose- and time-dependent reduction in the thickness of turbinate OE. These reductions were due to sustentacular cell loss, measured by terminal dUTP nick-end labeling (TUNEL) staining at 1-day postinstillation and caspase-3-dependent apoptosis of olfactory sensory neurons at 3 days postinstillation. A significant increase in cell proliferation was observed at 5 and 7 days postinstillation of NiSO(4) evidenced by BrdU incorporation. Treatment with purinergic receptor antagonists significantly reduced NiSO(4)-induced cell proliferation and posttreatment with ATP significantly increased cell proliferation. Furthermore, posttreatment with ATP had no effect on sustentacular cell viability but significantly reduced caspase-3-dependent neuronal apoptosis. In a bulbectomy-induced model of apoptosis, exogenous ATP produced a significant increase in cell proliferation that was not affected by purinergic receptor antagonists, suggesting that ATP is not released during bulbectomy-induced apoptosis. ATP is released following NiSO(4)-induced apoptosis and has neuroproliferative and neuroprotective functions. These data provide therapeutic strategies to alleviate or cure the loss of olfactory function associated with exposure to nickel compounds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.