ArticleThe Journal of nutrition2010
Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women.
Article in The Journal of nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 9 syntheses or guidelines pooled it, 286 citations in OpenAlex.
- Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024Pooled it
- Effect of maternal vitamin D status on risk of adverse birth outcomes: a systematic review and dose-response meta-analysis of observational studies.European journal of nutrition · 2022Pooled it
- The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Examining the predictive accuracy of metabolomics for small-for-gestational-age babies: a systematic review.BMJ open · 2019Pooled it
- Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019Pooled it
- Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review.Journal of assisted reproduction and genetics · 2015Pooled it
- Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis.Paediatric and perinatal epidemiology · 2012Pooled it
- Vitamin D in pregnancy: current concepts.Current opinion in obstetrics & gynecology · 2012Pooled it
- Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2012Pooled it
- Trial
- Maternal Obesity, 25-Hydroxy Vitamin D Concentration, and Bone Density in Breastfeeding Dyads.The Journal of pediatrics · 2017Trial
- Trial
- Early pregnancy vitamin D status and risk for adverse maternal and infant outcomes in a bi-ethnic cohort: the Behaviors Affecting Baby and You (B.A.B.Y.) Study.The British journal of nutrition · 2015Trial
- Maternal calcium metabolic stress and fetal growth.The American journal of clinical nutrition · 2014Trial
- Typical prenatal vitamin D supplement intake does not prevent decrease of plasma 25-hydroxyvitamin D at birth.Journal of the American College of Nutrition · 2014Trial
- Maternal vitamin D status and small-for-gestational-age offspring in women at high risk for preeclampsia.Obstetrics and gynecology · 2014Trial
- A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina.American journal of obstetrics and gynecology · 2013Trial
- Beyond deficiency prevention: meteorological determinants and nonlinear associations of maternal vitamins D, A, and E with perinatal outcomes in 10,824 Chinese pregnancies.Frontiers in nutrition · 2026Article
- Maternal vitamin D status, fetal growth patterns, and adverse pregnancy outcomes in a multisite prospective pregnancy cohort.The American journal of clinical nutrition · 2025Article
- Loss of maternal calcitriol reversibly alters early offspring growth and skeletal development in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Maternal vitamin D deficiency has been associated with numerous adverse health outcomes, but its association with fetal growth restriction remains uncertain. We sought to elucidate the association between maternal serum 25-hydroxyvitamin D [25(OH)D] concentrations in early pregnancy and the risk of small-for-gestational age birth (SGA) and explore the association between maternal single nucleotide polymorphisms (SNP) in the vitamin D receptor (VDR) gene and the risk of SGA. We conducted a nested case-control study of nulliparous pregnant women with singleton pregnancies who delivered SGA infants (n = 77 white and n = 34 black) or non-SGA infants (n = 196 white and n = 105 black). Women were followed from <16 wk gestation to delivery. Women's banked sera at <22 wk were newly measured for 25(OH)D and DNA extracted for VDR genotyping. SGA was defined as live-born infants that were <10th percentile of birth weight according to nomograms based on gender and gestational age. After confounder adjustment, there was a U-shaped relation between serum 25(OH)D and risk of SGA among white mothers, with the lowest risk from 60 to 80 nmol/L. Compared with serum 25(OH)D 37.5-75 nmol/L, SGA odds ratios (95% CI) for levels <37.5 and >75 nmol/L were 7.5 (1.8, 31.9) and 2.1 (1.2, 3.8), respectively. There was no relation between 25(OH)D and SGA risk among black mothers. One SNP in the VDR gene among white women and 3 SNP in black women were significantly associated with SGA. Our results suggest that vitamin D has a complex relation with fetal growth that may vary by race.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.