ArticleProceedings. Biological sciences2010
Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis.
Article in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- No innocent bystanders: pertussis vaccination and evolutionary parallelisms betweenMicrobial genomics · 2025Article
- Pertussis vaccines, epidemiology and evolution.Nature reviews. Microbiology · 2024Review
- Molecular epidemiology and genomic features ofFrontiers in microbiology · 2024Article
- Evolution and Conservation ofFrontiers in microbiology · 2020Review
- Article
- Immunomodulation as a Novel Strategy for Prevention and Treatment ofFrontiers in immunology · 2019Review
- The Adjuvant Bordetella Colonization Factor A Attenuates Alum-Induced Th2 Responses and Enhances Bordetella pertussis Clearance from Mouse Lungs.Infection and immunity · 2018Article
- Outer-Membrane-Vesicle-Associated O Antigen, a Crucial Component for Protecting AgainstFrontiers in immunology · 2018Article
- Bordetella parapertussis outbreak in Southeastern Minnesota and the United States, 2014.Medicine · 2017Observational
- Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis.Iranian journal of pediatrics · 2016Review
- The pertussis enigma: reconciling epidemiology, immunology and evolution.Proceedings. Biological sciences · 2016Review
- Widespread Bordetella parapertussis Infections-Wisconsin, 2011-2012: Clinical and Epidemiologic Features and Antibiotic Use for Treatment and Prevention.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Bordetella parapertussis outbreak in Bisham, Pakistan in 2009-2010: fallout of the 9/11 syndrome.Epidemiology and infection · 2015Article
- Within-host dynamics of infection: from ecological insights to evolutionary predictions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Bordetella parapertussis survives inside human macrophages in lipid raft-enriched phagosomes.Infection and immunity · 2014Article
- Pertussis outbreak, southeastern Minnesota, 2012.Mayo Clinic proceedings · 2014Article
- Bordetella parapertussis survives the innate interaction with human neutrophils by impairing bactericidal trafficking inside the cell through a lipid raft-dependent mechanism mediated by the lipopolysaccharide O antigen.Infection and immunity · 2012Article
- Enhancement of Bordetella parapertussis infection by Bordetella pertussis in mixed infection of the respiratory tract.FEMS immunology and medical microbiology · 2011Article
- An ecological and conservation perspective on advances in the applied virology of zoonoses.Viruses · 2011Review
- Consequences of immunopathology for pathogen virulence evolution and public health: malaria as a case study.Evolutionary applications · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Despite over 50 years of population-wide vaccination, whooping cough incidence is on the rise. Although Bordetella pertussis is considered the main causative agent of whooping cough in humans, Bordetella parapertussis infections are not uncommon. The widely used acellular whooping cough vaccines (aP) are comprised solely of B. pertussis antigens that hold little or no efficacy against B. parapertussis. Here, we ask how aP vaccination affects competitive interactions between Bordetella species within co-infected rodent hosts and thus the aP-driven strength and direction of in-host selection. We show that aP vaccination helped clear B. pertussis but resulted in an approximately 40-fold increase in B. parapertussis lung colony-forming units (CFUs). Such vaccine-mediated facilitation of B. parapertussis did not arise as a result of competitive release; B. parapertussis CFUs were higher in aP-relative to sham-vaccinated hosts regardless of whether infections were single or mixed. Further, we show that aP vaccination impedes host immunity against B. parapertussis-measured as reduced lung inflammatory and neutrophil responses. Thus, we conclude that aP vaccination interferes with the optimal clearance of B. parapertussis and enhances the performance of this pathogen. Our data raise the possibility that widespread aP vaccination can create hosts more susceptible to B. parapertussis infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.