ArticleProceedings. Biological sciences2010
A naturally occurring variant of Hsp90 that is associated with decanalization.
Article in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective.Journal of molecular biology · 2024Review
- Article
- It's not magic - Hsp90 and its effects on genetic and epigenetic variation.Seminars in cell & developmental biology · 2019Review
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
- Analysis of Epistasis in Natural Traits Using Model Organisms.Trends in genetics : TIG · 2018Review
- A sibling method for identifying vQTLs.PloS one · 2018Article
- Downregulation of the evolutionary capacitor Hsp90 is mediated by social cues.Proceedings. Biological sciences · 2015Article
- On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms.Annual review of ecology, evolution, and systematics · 2014Article
- Cryptic genetic variation: evolution's hidden substrate.Nature reviews. Genetics · 2014Review
- Environmental disruption of host-microbe co-adaptation as a potential driving force in evolution.Frontiers in genetics · 2014Article
- Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution.Trends in genetics : TIG · 2013Review
- Molecular mechanisms of robustness in plants.Current opinion in plant biology · 2013Review
- The conditional nature of genetic interactions: the consequences of wild-type backgrounds on mutational interactions in a genome-wide modifier screen.PLoS genetics · 2013Article
- Hsp90 depletion goes wild.BMC biology · 2012Article
- Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations.BMC evolutionary biology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heat shock protein Hsp90 has been the focus of many studies since it was suggested that it acts to mediate the buffering of phenotypic variation. Hsp90-mediated buffering may result in the accumulation of cryptic genetic variation that, when released either as a consequence of environmental or genetic stress, increases the evolvability of a population. Recent studies using laboratory-induced mutations of Hsp90 and/or chemical inhibition to disrupt Hsp90 function confirm that Hsp90 can buffer cryptic genetic variation. We have previously identified a naturally occurring variant in the charged linker region of the Hsp90 gene, and now examine whether this variant is associated with altered levels of trait variability. The variant is associated with the release of cryptic genetic variation for canalized morphological (bristle) traits, but not for uncanalized morphological (wing and bristle) traits, and the effect on canalized traits depends on culture temperature. This suggests that natural genetic variation in Hsp90 may mediate the evolution of canalized morphological traits even if it does not influence the expression of variation for uncanalized traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.