ArticleRespiratory research2010
Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury model.
Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- The impact of ventilation mode on systemic inflammation and organ dysfunction in a porcine model of abdominal sepsis-associated acute respiratory distress syndrome.Intensive care medicine experimental · 2026Article
- Identification and Validation of Liver Transplantation-Induced Acute Lung Injury Biomarkers Using a Bioinformatics and Experimental Approach.Annals of transplantation · 2026Article
- Mining the key genes for ventilator-induced lung injury using co-expression network analysis.Bioscience reports · 2021Article
- Review
- WISP1 and TLR4 on Macrophages Contribute to Ventilator-Induced Lung Injury.Inflammation · 2020Article
- Dexmedetomidine reduces ventilator-induced lung injury (VILI) by inhibiting Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signaling pathway.Bosnian journal of basic medical sciences · 2018Article
- Selective Role of Vinculin in Contractile Mechanisms of Endothelial Permeability.American journal of respiratory cell and molecular biology · 2016Article
- Context Specific and Differential Gene Co-expression Networks via Bayesian Biclustering.PLoS computational biology · 2016Article
- [Ventilation as a trigger for organ dysfunction and sepsis].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2016Review
- Evaluating the effects of protective ventilation on organ-specific cytokine production in porcine experimental postoperative sepsis.BMC pulmonary medicine · 2015Article
- Mechanical ventilation modulates Toll-like receptors 2, 4, and 9 on alveolar macrophages in a ventilator-induced lung injury model.Journal of thoracic disease · 2015Article
- Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury.PloS one · 2015Article
- The receptor for advanced glycation end products in ventilator-induced lung injury.Intensive care medicine experimental · 2014Article
- Ventilator-induced lung injury. Similarity and differences between children and adults.American journal of respiratory and critical care medicine · 2014Article
- Soluble platelet-endothelial cell adhesion molecule-1, a biomarker of ventilator-induced lung injury.Critical care (London, England) · 2014Article
- IL-1β processing in mechanical ventilation-induced inflammation is dependent on neutrophil factors rather than caspase-1.Intensive care medicine experimental · 2013Article
- Aggravation of myocardial dysfunction by injurious mechanical ventilation in LPS-induced pneumonia in rats.Respiratory research · 2013Article
- Inhaled aerosolized insulin ameliorates hyperglycemia-induced inflammatory responses in the lungs in an experimental model of acute lung injury.Critical care (London, England) · 2013Article
- Novel approaches to minimize ventilator-induced lung injury.BMC medicine · 2013Review
- High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious experimental studies have shown that injurious mechanical ventilation has a direct effect on pulmonary and systemic immune responses. How these responses are propagated or attenuated is a matter of speculation. The goal of this study was to determine the contribution of mechanical ventilation in the regulation of Toll-like receptor (TLR) signaling and interleukin-1 receptor associated kinase-3 (IRAK-3) during experimental ventilator-induced lung injury.
methodsProspective, randomized, controlled animal study using male, healthy adults Sprague-Dawley rats weighing 300-350 g. Animals were anesthetized and randomized to spontaneous breathing and to two different mechanical ventilation strategies for 4 hours: high tidal volume (VT) (20 ml/kg) and low VT (6 ml/kg). Histological evaluation, TLR2, TLR4, IRAK3 gene expression, IRAK-3 protein levels, inhibitory kappa B alpha (IkappaBalpha), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL6) gene expression in the lungs and TNF-alpha and IL-6 protein serum concentrations were analyzed.
resultsHigh VT mechanical ventilation for 4 hours was associated with a significant increase of TLR4 but not TLR2, a significant decrease of IRAK3 lung gene expression and protein levels, a significant decrease of IkappaBalpha, and a higher lung expression and serum concentrations of pro-inflammatory cytokines.
conclusionsThe current study supports an interaction between TLR4 and IRAK-3 signaling pathway for the over-expression and release of pro-inflammatory cytokines during ventilator-induced lung injury. Our study also suggests that injurious mechanical ventilation may elicit an immune response that is similar to that observed during infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.