ArticleThe Biochemical journal2010
Adaptor protein 2 regulates receptor-mediated endocytosis and cyst formation in Giardia lamblia.
Article in The Biochemical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Two Centrins and Their Posttranslational Modification Modulate the Cell Cycle of Giardia lamblia.MicrobiologyOpen · 2025Article
- Antiparasitic activity of Colombian Amazon palm extracts againstFrontiers in microbiology · 2025Article
- Cytotoxic effects of ivermectin onFrontiers in microbiology · 2024Article
- Identification of Actin Filament-Associated Proteins in Giardia lamblia.Microbiology spectrum · 2021Article
- Article
- Socio-demographic influences on the prevalence of intestinal parasitic infections among workers in Qatar.Parasites & vectors · 2021Article
- Lactoferrin and lactoferricin endocytosis halt Giardia cell growth and prevent infective cyst production.Scientific reports · 2018Article
- Membrane-Associated Proteins inGenes · 2018Review
- Environmental and socio-demographic individual, family and neighborhood factors associated with children intestinal parasitoses at Iguazú, in the subtropical northern border of Argentina.PLoS neglected tropical diseases · 2017Article
- Static Clathrin Assemblies at the Peripheral Vacuole-Plasma Membrane Interface of the Parasitic Protozoan Giardia lamblia.PLoS pathogens · 2016Article
- The genome of the myxosporean Thelohanellus kitauei shows adaptations to nutrient acquisition within its fish host.Genome biology and evolution · 2014Article
- Identification of Giardia lamblia DHHC proteins and the role of protein S-palmitoylation in the encystation process.PLoS neglected tropical diseases · 2014Article
- Article
- The giardial VPS35 retromer subunit is necessary for multimeric complex assembly and interaction with the vacuolar protein sorting receptor.Biochimica et biophysica acta · 2013Article
- Ubiquitination dynamics in the early-branching eukaryote Giardia intestinalis.MicrobiologyOpen · 2013Article
- Receptor-mediated endocytosis and trafficking between endosomal-lysosomal vacuoles in Giardia lamblia.Parasitology research · 2013Article
- The proteome landscape of Giardia lamblia encystation.PloS one · 2013Article
- Vacuolar protein sorting receptor in Giardia lamblia.PloS one · 2012Article
- Lysosomal protein trafficking in Giardia lamblia: common and distinct features.Frontiers in bioscience (Elite edition) · 2012Review
- An actin cytoskeleton with evolutionarily conserved functions in the absence of canonical actin-binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The parasite Giardia lamblia possesses PVs (peripheral vacuoles) that function as both endosomes and lysosomes and are implicated in the adaptation, differentiation and survival of the parasite in different environments. The mechanisms by which Giardia traffics essential proteins to these organelles and regulates their secretion have important implications in the control of parasite dissemination. In the present study, we describe the participation of the heterotetrameric clathrin-adaptor protein gAP2 (Giardia adaptor protein 2) complex in lysosomal protein trafficking. A specific monoclonal antibody against the medium subunit (gmu2) of gAP2 showed localization of this complex to the PVs, cytoplasm and plasma membrane in the growing trophozoites. gAP2 also co-localized with clathrin in the PVs, suggesting its involvement in endocytosis. Uptake experiments using standard molecules for the study of endocytosis revealed that gAP2 specifically participated in the endocytosis of LDL (low-density lipoprotein). Targeted down-regulation of the gene encoding gmu2 in growing and encysting trophozoites resulted in a large decrease in the amount of cell growth and cyst wall formation, suggesting a distinct mechanism in which gAP2 is directly involved in both endocytosis and vesicular trafficking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.