ArticleThe Journal of infectious diseases2010
Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era--United States, 2000-2005.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Abdominal symptoms of invasive meningococcal disease are associated with the induction of plasminogen activator inhibitor-1 in omental adipocytes.BMC infectious diseases · 2026Article
- Convergent impact of vaccination and antibiotic pressures on pneumococcal populations.Cell chemical biology · 2024Review
- Characterisation and Immunogenicity ofFrontiers in immunology · 2024Article
- Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape inMicroorganisms · 2023Review
- Development of a non-biased, high-throughput ELISA for the rapid evaluation of immunogenicity and cross-reactivity.Journal of immunological methods · 2021Article
- A Narrative Review of the W, X, Y, E, and NG of Meningococcal Disease: Emerging Capsular Groups, Pathotypes, and Global Control.Microorganisms · 2021Review
- A Narrative Review of the Molecular Epidemiology and Laboratory Surveillance of Vaccine Preventable Bacterial Meningitis Agents:Microorganisms · 2021Review
- Lung abscess due to Neisseria meningitidis serogroup X-unexpected virulence of a commensal resulting from putative serogroup B capsular switching.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Invasive meningococcal disease in Italy: from analysis of national data to an evidence-based vaccination strategy.Journal of preventive medicine and hygiene · 2020Article
- Serogroup A meningococcal conjugate vaccines: building sustainable and equitable vaccine strategies.Expert review of vaccines · 2020Review
- Insights on Population Structure and Within-Host Genetic Changes among Meningococcal Carriage Isolates from U.S. Universities.mSphere · 2020Article
- Article
- Molecular epidemiology and expression of capsular polysaccharides in Staphylococcus aureus clinical isolates in the United States.PloS one · 2019Article
- Population structure of invasive Neisseria meningitidis in the United States, 2011-15.The Journal of infection · 2018Article
- Whole genome sequencing for investigations of meningococcal outbreaks in the United States: a retrospective analysis.Scientific reports · 2018Article
- Neisseria meningitidis disease-associated clones in Amazonas State, Brazil.Infectious diseases (London, England) · 2018Article
- The amino acid selected for generating mutant TbpB antigens defective in binding transferrin can compromise the in vivo protective capacity.Scientific reports · 2018Article
- Vaccine prevention of meningococcal disease in Africa: Major advances, remaining challenges.Human vaccines & immunotherapeutics · 2018Review
- Genetic Analysis of Neisseria meningitidis Sequence Type 7 Serogroup X Originating from Serogroup A.Infection and immunity · 2017Article
- Regulation of capsule in Neisseria meningitidis.Critical reviews in microbiology · 2016Review
Corrections and comments
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Authors and funding
11 authors.
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Abstract
backgroundA quadrivalent meningococcal conjugate vaccine (MCV4) was licensed in the United States in 2005; no serogroup B vaccine is available. Neisseria meningitidis changes its capsular phenotype through capsular switching, which has implications for vaccines that do not protect against all serogroups.
methodsMeningococcal isolates from 10 Active Bacterial Core surveillance sites from 2000 through 2005 were analyzed to identify changes occurring after MCV4 licensure. Isolates were characterized by multilocus sequence typing (MLST) and outer membrane protein gene sequencing. Isolates expressing capsular polysaccharide different from that associated with the MLST lineage were considered to demonstrate capsular switching.
resultsAmong 1160 isolates, the most common genetic lineages were the sequence type (ST)-23, ST-32, ST-11, and ST-41/44 clonal complexes. Of serogroup B and Y isolates, 8 (1.5%) and 3 (0.9%), respectively, demonstrated capsular switching, compared with 36 (12.9%) for serogroup C (P < .001); most serogroup C switches were from virulent serogroup B and/or serogroup Y lineages.
conclusionsA limited number of genetic lineages caused the majority of invasive meningococcal infections. A substantial proportion of isolates had evidence of capsular switching. The high prevalence of capsular switching requires surveillance to detect changes in the meningococcal population structure that may affect the effectiveness of meningococcal vaccines.
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