ArticleDigestive diseases and sciences2010
Systemic inflammatory response associated with distant metastasis of T1 or T2 colorectal cancer.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 16 citations in OpenAlex.
- Biological resonance for cancer metastasis, a new hypothesis based on comparisons between primary cancers and metastases.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013Article
- Glasgow Prognostic Score (GPS) can be a useful indicator to determine prognosis of patients with colorectal carcinoma.International surgeryArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are currently no studies examining the relationship between systemic inflammatory response and distant metastasis in colorectal cancer patients.
aimsThe aim of this study was to evaluate the association of a systemic inflammatory response on distant metastasis by examining clinicopathological factors in patients with colorectal cancer infiltrating the submucosal layer (T1) or the proper muscular layer (T2).
methodsUnivariate analysis was performed to evaluate the influence of a systemic inflammatory response on distant metastasis in patients with T1 or T2 colorectal cancer using collected clinicopathological data.
resultsBetween 1993 and 2008, 156 patients with pathologically diagnosed T1 or T2 colorectal cancer were enrolled. Univariate analysis using clinicopathological factors and Glasgow Prognostic Score (GPS) (0, 1/2) demonstrated that, as well as lymph node metastasis, administration of oral anti-cancer drug and CEA, CRP (odds ratio, 36.25; 95% CI 4.026-326.4; P = 0.001) and GPS (odds ratio, 24.50; 95% CI 1.715-349.9; P =0.018) were associated with distant metastasis.
conclusionsCRP and GPS are associated with distant metastasis of T1 or T2 colorectal cancer. Because of the small number of patients with stage IV disease (n =4), a multi-center retrospective study is needed to confirm these findings.
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