ReviewPharmaceutical research2010
Bitter melon: antagonist to cancer.
Review in Pharmaceutical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 91 citations in OpenAlex.
- Targeting Triple-Negative Breast Cancer with Momordicine-I for Therapeutic Gain in Preclinical Models.Cancers · 2025Article
- Article
- Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes.Molecular cancer therapeutics · 2024Article
- Exploring the mechanism of action bitter melon in the treatment of breast cancer by network pharmacology.World journal of experimental medicine · 2023Article
- Investigation of cell cytotoxic activity and molecular mechanism of 5β,19-epoxycucurbita-6,23(Pharmaceutical biology · 2022Article
- Spectroscopic contribution to glyphosate toxicity profile and the remedial effects of Momordica charantia.Scientific reports · 2022Article
- Therapeutic Investigation of Standardized Aqueous Methanolic Extract of Bitter Melon (Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Article
- Diverse roles of bitter melon (Journal of cancer metastasis and treatment · 2021Article
- Bitter Melon (Cancers · 2020Review
- Momordicoside G Regulates Macrophage Phenotypes to Stimulate Efficient Repair of Lung Injury and Prevent Urethane-Induced Lung Carcinoma Lesions.Frontiers in pharmacology · 2019Article
- Review
- Bitter melon extract inhibits breast cancer growth in preclinical model by inducing autophagic cell death.Oncotarget · 2017Article
- Bitter Melon Enhances Natural Killer-Mediated Toxicity against Head and Neck Cancer Cells.Cancer prevention research (Philadelphia, Pa.) · 2017Article
- Bitter melon protects against ER stress in LS174T colonic epithelial cells.BMC complementary and alternative medicine · 2017Article
- Protective effect ofFood & nutrition research · 2017Article
- Antifungal activity of Momordica charantia seed extracts toward the pathogenic fungus Fusarium solani L.Journal of food and drug analysis · 2016Article
- Immunomodulatory role of bitter melon extract in inhibition of head and neck squamous cell carcinoma growth.Oncotarget · 2016Article
- A triterpenoid from wild bitter gourd inhibits breast cancer cells.Scientific reports · 2016Article
- Antimutagenic Compounds of White Shrimp (Litopenaeus vannamei): Isolation and Structural Elucidation.Evidence-based complementary and alternative medicine : eCAM · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of cancer is increasing worldwide, in spite of substantial progress in the development of anti-cancer therapies. One approach to control cancer could be its prevention by diet, which inhibits one or more neoplastic events and reduces cancer risk. Dietary compounds offer great potential in the fight against cancer by inhibiting the carcinogenesis process through the regulation of cell homeostasis and cell-death machineries. For centuries, Ayurveda (Indian traditional medicine) has recommended the use of bitter melon (Momordica charantia) as a functional food to prevent and treat diabetes and associated complications. It is noteworthy to mention that bitter melon extract has no-to-low side effects in animals as well as in humans. The anti-tumor activity of bitter melon has recently begun to emerge. This review focuses on recent advancements in cancer chemopreventive and anti-cancer efficacy of bitter melon and its active constituents. Several groups of investigators have reported that treatment of bitter-melon-related products in a number of cancer cell lines induces cell cycle arrest and apoptosis without affecting normal cell growth. Therefore, the effect of bitter melon should be beneficial for health, and use of the non-modified dietary product is cost effective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.