ArticleFrontiers in neuroscience2009
Untangling neural networks with dual retrograde transsynaptic viral infection.
Article in Frontiers in neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled.eLife · 2022Article
- Intersectional, anterograde transsynaptic targeting of neurons receiving monosynaptic inputs from two upstream regions.Communications biology · 2022Article
- Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools.eLife · 2021Article
- Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses.Neuroscience bulletin · 2019Review
- Gene Expression Profiling with Cre-Conditional Pseudorabies Virus Reveals a Subset of Midbrain Neurons That Participate in Reward Circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Pseudotyped Lentiviral Vectors for Retrograde Gene Delivery into Target Brain Regions.Frontiers in neuroanatomy · 2017Review
- Increased transgene expression level of rabies virus vector for transsynaptic tracing.PloS one · 2017Article
- Brain-Wide Mapping of Axonal Connections: Workflow for Automated Detection and Spatial Analysis of Labeling in Microscopic Sections.Frontiers in neuroinformatics · 2016Article
- An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology.Brain structure & function · 2015Article
- Long-term Cre-mediated retrograde tagging of neurons using a novel recombinant pseudorabies virus.Frontiers in neuroanatomy · 2014Article
- Article
- Rabies virus vector transgene expression level and cytotoxicity improvement induced by deletion of glycoprotein gene.PloS one · 2013Article
- Frontal lobe and posterior parietal contributions to the cortico-cerebellar system.Cerebellum (London, England) · 2012Review
- Mapping the connectome: multi-level analysis of brain connectivity.Frontiers in neuroinformatics · 2012Article
- Article
- Rabies virus as a research tool and viral vaccine vector.Advances in virus research · 2011Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using recombinant rabies virus (RV), we developed a dual transsynaptic retrograde tracing technique in the rat central nervous system. Two strains of recombinant RV, injected into two separate loci of the brain, were taken up through axon terminals and carried retrogradely and transsynaptically from neuron to neuron. Each viral strain expresses a unique marker in infected neurons. Therefore, neurons that project transsynaptically to two brain loci can be detected by double-labeling. In this review, we will introduce the advantage of dual viral tracing by recombinant RV, and will also address some potential weaknesses of this technique. Although false negative results may arise due to interference between two strains of RV, the ability of the recombinant RV to visualize the morphology of the infected cell and to infect primates in addition to rodents will make this technique a potential tool to provide new insights into the complex organization of brain networks.
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