ArticleJournal of exposure science & environmental epidemiology
Internal exposure to pollutants and sexual maturation in Flemish adolescents.
Article in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: a systematic review and meta-analysis.Human reproduction update · 2022Pooled it
- A Systematic Literature Review of Factors Affecting the Timing of Menarche: The Potential for Climate Change to Impact Women's Health.International journal of environmental research and public health · 2020Pooled it
- Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep.Environmental toxicology and pharmacology · 2023Article
- Impact of Chemicals on the Age of Menarche: A Literature Review.Children (Basel, Switzerland) · 2023Review
- Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats.Frontiers in endocrinology · 2023Article
- Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture.Nutrients · 2021Review
- Sex differences in the association of measures of sexual maturation to common toxicants: Lead, dichloro-diphenyl-trichloroethane (DDT), dichloro-diphenyl-dichloroethylene (DDE), and polychlorinated biphenyls (PCBs).Annals of human biology · 2021Review
- Cellular and molecular features of EDC exposure: consequences for the GnRH network.Nature reviews. Endocrinology · 2021Review
- Vitamin D Status in Children With Short Stature: Accurate Determination of Serum Vitamin D Components Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.Frontiers in endocrinology · 2021Article
- Early-life exposure to endocrine-disrupting chemicals and pubertal development in girls.Annals of pediatric endocrinology & metabolism · 2019Article
- Organochlorine pesticides exposure in female adolescents: potential impact on sexual hormones and interleukin-1 levels.Immunologic research · 2018Observational
- The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children's Study.Reviews on environmental health · 2017Review
- Serum Levels of Persistent Organic Pollutants and Insulin Secretion among Children Age 7-9 Years: A Prospective Cohort Study.Environmental health perspectives · 2016Article
- Associations of Peripubertal Serum Dioxin and Polychlorinated Biphenyl Concentrations with Pubertal Timing among Russian Boys.Environmental health perspectives · 2016Article
- Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys.Environmental health perspectives · 2015Article
- Brominated Flame Retardants and Other Persistent Organohalogenated Compounds in Relation to Timing of Puberty in a Longitudinal Study of Girls.Environmental health perspectives · 2015Article
- Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys.Environment international · 2014Article
- Gynaecomastia--pathophysiology, diagnosis and treatment.Nature reviews. Endocrinology · 2014Review
- Relationships of polychlorinated biphenyls and dichlorodiphenyldichloroethylene (p,p'-DDE) with testosterone levels in adolescent males.Environmental health perspectives · 2014Article
- Potential external contamination with bisphenol A and other ubiquitous organic environmental chemicals during biomonitoring analysis: an elusive laboratory challenge.Environmental health perspectives · 2013Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flanders is densely populated with much industry and intensive farming. Sexual maturation of adolescents (aged 14-15 years) was studied in relation to internal exposure to pollutants. Serum levels of pollutants and sex hormones were measured in 1679 participants selected as a random sample of the adolescents residing in the study areas. Data on sexual development were obtained from the medical school examination files. Self-assessment questionnaires provided information on health, use of medication and lifestyle factors. In boys, serum levels of hexachlorobenzene (HCB), p,p'-DDE and polychlorinated biphenyls (sum of marker PCB138, 153 and 180) were significantly and positively associated with pubertal staging (pubic hair and genital development). Higher levels of serum HCB and blood lead were associated with, respectively, a lower and a higher risk of gynecomastia. In girls, significant and negative associations were detected between blood lead and pubic hair development; higher exposure to PCBs was significantly associated with a delay in timing of menarche. Environmental exposures to pollutants at levels actually present in the Flemish population are associated with measurable effects on pubertal development. However, further understanding of toxic mode of action and sensitive windows of exposure is needed to explain the current findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.