ArticleEuropean journal of clinical nutrition2010
Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women.
Article in European journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Soy Product Consumption and the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies.Nutrients · 2024Pooled it
- Vitamin D and VDR in Gynecological Cancers-A Systematic Review.International journal of molecular sciences · 2017Pooled it
- Impact of Cholecalciferol Supplementation on Radiotherapy Outcomes in Advanced Cervical Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Effects of Long-Term Vitamin D Supplementation on Regression and Metabolic Status of Cervical Intraepithelial Neoplasia: a Randomized, Double-Blind, Placebo-Controlled Trial.Hormones & cancer · 2017Trial
- The Role of Nutrition in HPV Infection and Cervical Cancer Development: A Review of Protective Dietary Factors.Cancers · 2025Review
- Article
- 25-Hydroxycholecalciferol Serum Level Shows an Inverse Relationship with High-Grade Uterine Cervical Dysplasia in HIV-Uninfected Black Women in South Africa.Journal of clinical medicine · 2025Article
- The influence of nutrition on HPV-associated inflammation: a systematic review and meta-analysis.Frontiers in nutrition · 2025Article
- Vitamin D and Its Receptors in Cervical Cancer.Journal of Cancer · 2024Review
- Risk factors for the development of cervical cancer: analysis of the evidence.Frontiers in oncology · 2024Review
- Association of dietary intake and cervical cancer: a prevention strategy.Infectious agents and cancer · 2023Article
- The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm.Healthcare (Basel, Switzerland) · 2023Review
- The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer.International journal of molecular sciences · 2023Review
- Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study.Journal of Cancer · 2021Article
- The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development.Medicina (Kaunas, Lithuania) · 2020Review
- The Effects of the Dietary and Nutrient Intake on Gynecologic Cancers.Healthcare (Basel, Switzerland) · 2019Review
- Knowledge, Attitudes and Practices of Women in the Southern Region of Saudi Arabia Regarding Cervical Cancer and the Pap Smear TestAsian Pacific journal of cancer prevention : APJCP · 2019Article
- [HPV infection in women : Diagnostics, treatment and the relevance of vaccination].Der Urologe. Ausg. A · 2018Review
- Comparison of weighed food record procedures for the reference methods in two validation studies of food frequency questionnaires.Journal of epidemiology · 2017Article
- Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression.Oncology research · 2014Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesTo examine the association between dietary calcium and vitamin D intake and cervical neoplasia risk, we conducted a case-control study. SUBJECTS/
methodsWe selected 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls. Dietary information was collected using a semiquantitative food-frequency questionnaire (FFQ). The effect on cervical neoplasia risk was evaluated using conditional logistic regression models.
resultsThe inverse association between invasive carcinoma and milk, yogurt and fish was observed. On the other hand, the marginally significant inverse association between CIN3 and tofu and green leafy vegetables was observed. Compared with the lowest quartile (Q1) of calcium intake, adjusted odds ratios (ORs) for each of the three upper quartiles (Q2, Q3 and Q4) on invasive carcinoma risk were 0.86 (95% confidence interval (CI) 0.63-1.17), 0.50 (95% CI 0.34-0.73) and 0.68 (95% CI 0.48-0.97), respectively (P for trend=0.004). However, no association between calcium and cancer risk was evident among CIN3 cases (P for trend=0.528). Vitamin D intake showed a similar inverse association (Q2: OR 1.03, 95% CI 0.74-1.44; Q3: OR 0.80, 95% CI 0.56-1.15; and Q4: OR 0.64, 95% CI 0.43-0.94; P for trend=0.013). Similar to calcium, no association between vitamin D intake among CIN3 was evident (P for trend=0.109). An inverse association with calcium was evident in women whose vitamin D intake was low. However, this combined effect was not significant (invasive carcinoma: interaction P=0.819; and CIN3: interaction P=0.101).
conclusionWe found an inverse association between dietary calcium and vitamin D intake and cervical neoplasia risk among a group of Japanese women.
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Registered trials
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