Trial reportBritish journal of cancer2010
Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL).
Trial report in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Maternal Infection in Pregnancy and Childhood Leukemia: A Systematic Review and Meta-analysis.The Journal of pediatrics · 2020Pooled it
- Detection of AdenoviralInternational journal of molecular sciences · 2026Article
- Leukemic fusion genes repress viral gene expression and expel adenovirus from persistently infected human B lymphocytes but evidence of the virus lingers behind.bioRxiv : the preprint server for biology · 2025Article
- The E1a Adenoviral Gene Upregulates the Yamanaka Factors to Induce Partial Cellular Reprogramming.Cells · 2023Article
- DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation.Scientific reports · 2019Article
- Neonatal infection with species C adenoviruses confirmed in viable cord blood lymphocytes.PloS one · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundIn search of a proposed viral aetiology of childhood acute lymphoblastic leukaemia (ALL), the common species C adenoviruses were analysed in Guthrie cards.
methodsGuthrie cards from 243 children who later developed ALL and from 486 matched controls were collected and analysed by nested polymerase chain reaction for the presence of adenovirus DNA.
resultsAdenovirus DNA was reliably detected from only two subjects, both of whom developed ALL.
conclusionAdenovirus DNA is detected in Guthrie card samples at too low a frequency to reveal an association between adenovirus and the development of leukaemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.