ReviewMicrobiology and molecular biology reviews : MMBR2010
Biochemistry of microbial degradation of hexachlorocyclohexane and prospects for bioremediation.
Review in Microbiology and molecular biology reviews : MMBR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
83 citing papers in PubMed.
- Promoting Microbiology Literacy and Holistic Health: IMiLI and IMiLI-SAC Perspectives on Microbes, Diet, Lifestyle and Society-A 5-Year Journey.Microbial biotechnology · 2026Review
- Insights on Anabaena sp. PCC 7120 Responses to HCH Isomers: Tolerance, Degradation, and Dynamics on Potential lin Genes Expression.MicrobiologyOpen · 2025Article
- Characterization of the substrate specificity and regioselectivity of ring-cleavage of Pseudomonas putida DLL-E4 hydroquinone 1,2-dioxygenase (PnpC1C2).Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025Article
- Comprehensive review on Haloalkane dehalogenase (LinB): a β-hexachlorocyclohexane (HCH) degrading enzyme.Archives of microbiology · 2024Review
- Effectiveness of Biological Approaches for Removing Persistent Organic Pollutants from Wastewater: A Mini-Review.Microorganisms · 2024Review
- In Silico Analysis of the Phylogenetic and Physiological Characteristics of Sphingobium indicum B90A: A Hexachlorocyclohexane-Degrading Bacterium.Current microbiology · 2024Article
- Transgenic Arabidopsis thaliana plants expressing bacterial γ-hexachlorocyclohexane dehydrochlorinase LinA.BMC biotechnology · 2024Article
- Toward the development of a molecular toolkit for the microbial remediation of per-and polyfluoroalkyl substances.Applied and environmental microbiology · 2024Review
- Article
- Assessing HCH isomer uptake in Alnus glutinosa: implications for phytoremediation and microbial response.Scientific reports · 2024Article
- Revelation of bioremediation approaches for hexachlorocyclohexane degradation in soil.World journal of microbiology & biotechnology · 2023Review
- Uptake and Transformation of Hexachlorocyclohexane Isomers (HCHs) in Tree Growth Rings at a Contaminated Field Site.Environmental science & technology · 2023Article
- Responses of Anabaena sp. PCC7120 to lindane: Physiological effects and differential expression of potential lin genes.MicrobiologyOpen · 2023Article
- Mycelial nutrient transfer promotes bacterial co-metabolic organochlorine pesticide degradation in nutrient-deprived environments.The ISME journal · 2023Article
- Draft Genome Sequences of TwoMicrobiology resource announcements · 2022Article
- Influence of destructive bacteria and red clover (trifolium pratense L.) on the pesticides degradation in the soil.Environmental geochemistry and health · 2022Article
- Effects of Organochlorine Pesticide Residues in Maternal Body on Infants.Frontiers in endocrinology · 2022Review
- Draft Genome Sequence of Fusarium equiseti K3, a Fungal Species Isolated from Hexachlorocyclohexane-Contaminated Soil.Microbiology resource announcements · 2021Article
- Comparative proteomics unravelled the hexachlorocyclohexane (HCH) isomers specific responses in an archetypical HCH degrading bacterium Sphingobium indicum B90A.Environmental science and pollution research international · 2021Article
- Microbial debromination of hexabromocyclododecanes.Applied microbiology and biotechnology · 2021Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lindane, the gamma-isomer of hexachlorocyclohexane (HCH), is a potent insecticide. Purified lindane or unpurified mixtures of this and alpha-, beta-, and delta-isomers of HCH were widely used as commercial insecticides in the last half of the 20th century. Large dumps of unused HCH isomers now constitute a major hazard because of their long residence times in soil and high nontarget toxicities. The major pathway for the aerobic degradation of HCH isomers in soil is the Lin pathway, and variants of this pathway will degrade all four of the HCH isomers although only slowly. Sequence differences in the primary LinA and LinB enzymes in the pathway play a key role in determining their ability to degrade the different isomers. LinA is a dehydrochlorinase, but little is known of its biochemistry. LinB is a hydrolytic dechlorinase that has been heterologously expressed and crystallized, and there is some understanding of the sequence-structure-function relationships underlying its substrate specificity and kinetics, although there are also some significant anomalies. The kinetics of some LinB variants are reported to be slow even for their preferred isomers. It is important to develop a better understanding of the biochemistries of the LinA and LinB variants and to use that knowledge to build better variants, because field trials of some bioremediation strategies based on the Lin pathway have yielded promising results but would not yet achieve economic levels of remediation.
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