ArticleVascular pharmacology
Effect of high soy diet on the cerebrovasculature and endothelial nitric oxide synthase in the ovariectomized rat.
Article in Vascular pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- APOE4 negates the effects of ovarian hormones on cerebrovascular endothelial and mitochondrial function.The Journal of physiology · 2026Article
- Effects of dietary soy content on cerebral artery function and behavior in ovariectomized female mice.American journal of physiology. Heart and circulatory physiology · 2024Article
- Association of soy food with cardiovascular outcomes and all-cause mortality in a Chinese population: a nationwide prospective cohort study.European journal of nutrition · 2022Article
- Effects of Dietary Soy Protein Isolate Versus Isoflavones Alone on Poststroke Skilled Ladder Rung Walking and Cortical mRNA Expression Differ in Adult Male Rats.Journal of medicinal food · 2022Article
- Isoflavone Intake and the Risk of Coronary Heart Disease in US Men and Women: Results From 3 Prospective Cohort Studies.Circulation · 2020Article
- Protective effects ofIranian journal of basic medical sciences · 2019Article
- Article
- The Effects of Steroid Implant and Dietary Soybean Hulls on Estrogenic Activity of Sera of Steers Grazing Toxic Endophyte-Infected Tall Fescue Pasture.Frontiers in veterinary science · 2015Article
- The effects of soy extract on spatial learning and memory damage induced by global ischemia in ovariectomised rats.The Malaysian journal of medical sciences : MJMS · 2014Article
- Endothelial and neuronal nitric oxide synthases variably modulate the oestrogen-mediated control of blood pressure and cardiovascular autonomic control.Clinical and experimental pharmacology & physiology · 2014Article
- Androgens and the cerebrovasculature: modulation of vascular function during normal and pathophysiological conditions.Pflugers Archiv : European journal of physiology · 2013Review
- Endothelial nitric oxide synthase levels and their response to exercise in patients with slow coronary flow.Cardiovascular journal of AfricaArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
High soy (HS) diets are neuroprotective and promote vascular dilatation in the periphery. We hypothesized that an HS diet would promote vascular dilatation in the cerebrovasculature by mimicking estradiol's actions on the endothelial nitric oxide synthase (eNOS) system including increasing eNOS expression and decreasing caveolin-1 expression to increase nitric oxide (NO) production. Ovariectomized rats were fed HS or a soy-free diet (SF)+/-low physiological estradiol (E2) for 4weeks. Neither E2 nor HS altered middle cerebral artery (MCA) structure or vascular responses to acetylcholine, serotonin, or phenylephrine. Estradiol enhanced bradykinin-induced relaxation in an eNOS-dependent manner. Although E2 and HS increased eNOS mRNA expression in the brain and cerebrovasculature, they had no effect on eNOS protein expression or phosphorylation in the MCA. However, E2 decreased caveolin-1 protein in the MCA. In MCAs neither E2 nor HS altered estrogen receptor (ER) alpha expression, but E2 did reduce ER beta levels. These data suggest that HS diets have no effect on vascular NO production, and that E2 may modulate basal NO production by reducing the expression of caveolin-1, an allosteric inhibitor of NOS activity. However, the effects of E2 and HS on the cerebrovasculature are small and may not underlie their protective actions in pathological states.
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