ArticleBiophysical journal2010
Transcription within condensed chromatin: Steric hindrance facilitates elongation.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress.Nature communications · 2024Article
- Mechanical determinants of chromatin topology and gene expression.Nucleus (Austin, Tex.) · 2022Review
- A spatially resolved stochastic model reveals the role of supercoiling in transcription regulation.PLoS computational biology · 2022Article
- Epigenetic regulation of inflammation in stroke.Therapeutic advances in neurological disorders · 2018Review
- DNA supercoiling during transcription.Biophysical reviews · 2016Article
- Topological diversity of chromatin fibers: Interplay between nucleosome repeat length, DNA linking number and the level of transcription.AIMS biophysics · 2015Article
- DNA topology in chromosomes: a quantitative survey and its physiological implications.Journal of mathematical biology · 2014Article
- Transcription-generated torsional stress destabilizes nucleosomes.Nature structural & molecular biology · 2014Article
- Critical dynamics in host-pathogen systems.Current topics in microbiology and immunology · 2013Review
- On the topology of chromatin fibres.Interface focus · 2012Article
- Recent advances in single molecule studies of nucleosomes.Current opinion in structural biology · 2012Review
- Nucleosome accessibility governed by the dimer/tetramer interface.Nucleic acids research · 2011Article
- DNA torsion as a feedback mediator of transcription and chromatin dynamics.Nucleus (Austin, Tex.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During eukaryotic transcription, RNA-polymerase activity generates torsional stress in DNA, having a negative impact on the elongation process. Using our previous studies of chromatin fiber structure and conformational transitions, we suggest that this torsional stress can be alleviated, thanks to a tradeoff between the fiber twist and nucleosome conformational transitions into an activated state named "reversome". Our model enlightens the origin of polymerase pauses, and leads to the counterintuitive conclusion that chromatin-organized compaction might facilitate polymerase progression. Indeed, in a compact and well-structured chromatin loop, steric hindrance between nucleosomes enforces sequential transitions, thus ensuring that the polymerase always meets a permissive nucleosomal state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.