ArticleBiophysical journal2010
An iris-like mechanism of pore dilation in the CorA magnesium transport system.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- A cleanroom sleeping environment's impact on markers of oxidative stress, immune dysregulation, and behavior in children with autism spectrum disorders.BMC complementary and alternative medicine · 2015Trial
- Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism.Nature structural & molecular biology · 2025Article
- Ligand and Residue Free Energy Perturbations Solve the Dual Binding Mode Proposal for an AThe journal of physical chemistry. B · 2025Article
- MRS2 missense variation at Asp216 abrogates inhibitory MgProtein science : a publication of the Protein Society · 2024Article
- Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms.Nature communications · 2023Article
- Molecular basis of MgNature communications · 2023Article
- Hyphal Growth inMicrobiology spectrum · 2023Article
- The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity.Life science alliance · 2023Article
- Slow conformational dynamics of the human AStructure (London, England : 1993) · 2022Article
- MgeLife · 2022Article
- Asymmetric CorA Gating Mechanism as Observed by Molecular Dynamics Simulations.Journal of chemical information and modeling · 2021Article
- Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models?PLoS computational biology · 2021Article
- Biophysical Insight on the Membrane Insertion of an Arginine-Rich Cell-Penetrating Peptide.International journal of molecular sciences · 2019Article
- Article
- Loss of cytosolic MgBiochimica et biophysica acta. General subjects · 2019Article
- Article
- Mapping the Interface of a GPCR Dimer: A Structural Model of the AFrontiers in pharmacology · 2018Article
- Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.Nature communications · 2017Article
- Article
- Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA.PLoS computational biology · 2015Article
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Authors and funding
5 authors.
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Abstract
Magnesium translocation across cell membranes is essential for numerous physiological processes. Three recently reported crystal structures of the CorA magnesium transport system revealed a surprising architecture, with a bundle of giant alpha-helices forming a 60-A-long pore that extends beyond the membrane before widening into a funnel-shaped cytosolic domain. The presence of divalent cations in putative intracellular regulation sites suggests that these structures correspond to the closed conformation of CorA. To examine the nature of the conduction pathway, we performed 110-ns molecular-dynamics simulations of two of these structures in a lipid bilayer with and without regulatory ions. The results show that a 15-A-long hydrophobic constriction straddling the membrane-cytosol interface constitutes a steric bottleneck whose location coincides with an electrostatic barrier opposing cation translocation. In one of the simulations, structural relaxation after the removal of regulatory ions led to concerted changes in the tilt of the pore helices, resulting in iris-like dilation and spontaneous hydration of the hydrophobic neck. This simple and robust mechanism is consistent with the regulation of pore opening by intracellular magnesium concentration, and explains the unusual architecture of CorA.
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