ArticleJournal of viral hepatitis2011
New trends of HCV infection in China revealed by genetic analysis of viral sequences determined from first-time volunteer blood donors.
Article in Journal of viral hepatitis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coalescent inference for infectious disease: meta-analysis of hepatitis C.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Pooled it
- Trial
- Prevalence and factors associated with hepatitis C among pregnant women in China: a cross-sectional study.Scientific reports · 2023Article
- Distribution pattern, molecular transmission networks, and phylodynamic of hepatitis C virus in China.PloS one · 2023Article
- HCV 6a was expanding and became the predominant subtype among blood donors between 2004 and 2019 in Guangdong, China.Virologica Sinica · 2022Article
- Phylogenetic signature and prevalence of natural resistance-associated substitutions for hepatitis C virus genotypes 3a and 3b in southwestern China.Journal of virus eradication · 2022Article
- Distribution and changes in hepatitis C virus genotype in China from 2010 to 2020.World journal of clinical cases · 2022Article
- Geographic Distribution of HCV Genotypes and Efficacy of Direct-Acting Antivirals in Chronic HCV-Infected Patients in North and Northeast China: A Real-World Multicenter Study.Canadian journal of gastroenterology & hepatology · 2022Article
- The distribution of hepatitis C virus infection in Shanghai, China: a time-spatial study.BMC infectious diseases · 2021Article
- Rapid and Sensitive Detection of Hepatitis C Virus in Clinical Blood Samples Using Reverse Transcriptase Polymerase Spiral Reaction.Journal of microbiology and biotechnology · 2020Article
- Subtype-Specific Prevalence of Hepatitis C Virus NS5A Resistance Associated Substitutions in Mainland China.Frontiers in microbiology · 2019Article
- Hepatitis C virus genotypes and subtypes circulating in Mainland China.Emerging microbes & infections · 2017Article
- Article
- Assessment of HCV genotypes in Yunnan Province of Southwest China.Virus genes · 2017Article
- Hepatitis C Virus in mainland China with an emphasis on genotype and subtype distribution.Virology journal · 2017Review
- Naturally Occurring Resistance-Associated Variants to Hepatitis C Virus Direct-Acting Antiviral Agents in Treatment-Naive HCV Genotype 6a-Infected Patients.BioMed research international · 2017Article
- Hepatitis C Virus Increases Free Fatty Acids Absorption and Promotes its Replication Via Down-Regulating GADD45α Expression.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Article
- Article
- The evolutionary patterns of hepatitis C virus subtype 2a and 6a isolates linked to an outbreak in China in 2012.Virology · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Recently, we studied hepatitis C virus (HCV) sera-prevalence among 559 890 first-time volunteer blood donors in China. From randomly selected 450 anti-HCV positive donors, we detected HCV RNA in 270 donors. In this study, we amplified HCV E1 and/or NS5B sequences from 236 of these donors followed by DNA sequencing and phylogenetic analysis. The results indicate new trends of HCV infection in China. The HCV genotype distribution differed according to the donors' region of origin. Among donors from Guangdong province, we detected subtypes 6a, 1b, 3a, 3b, 2a, and 1a at frequencies of 49.7%, 31.0%, 7.6%, 5.5%, 4.1%, and 2.1%, respectively. Among donors from outside Guangdong, we detected 1b, 2a, 6a, 3b, 3a, 6e, and 6n at frequencies 57.1%, 13.2%, 11.0%, 9.9%, 4.4%, 2.2%, and 2.2%, respectively. Although we found no significant differences among regions in age or gender, subtype 6a was more common (P < 0.001) in donors from Guangdong than those from elsewhere, whilst subtypes 1b (P < 0.02) and 2a (P < 0.001) were more frequent outside Guangdong. Disregarding origins, the male/female ratio was higher for subtype 6a-infected donors (P < 0.05) than for subtype 1b donors, whilst the mean age of subtype 2a donors was 8-10 years older (P < 0.05) than that for all other subtypes. Detailed phylogenetic analysis of our sequence data provides further insight into the transmission of HCV within China, and between China and other countries. The predominance of HCV 6a among blood donors in Guangdong is striking and mandates studies into risk factors for its acquisition.
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