ArticlePlatelets2010
Protein expression in platelets from six species that differ in their open canalicular system.
Article in Platelets, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Physiological factors affecting platelet-rich plasma variability in human and veterinary medicine.Frontiers in veterinary science · 2025Review
- The shear rate promotes pinocytosis of extracellular dextran in platelets.Clinical hemorheology and microcirculation · 2024Article
- Platelet-Derived Exosomes and Atherothrombosis.Frontiers in cardiovascular medicine · 2022Review
- Animal Models of Neointimal Hyperplasia and Restenosis: Species-Specific Differences and Implications for Translational Research.JACC. Basic to translational science · 2021Review
- Significant differences in single-platelet biophysics exist across species but attenuate during clot formation.Blood advances · 2021Article
- Alterations in platelet secretion differentially affect thrombosis and hemostasis.Blood advances · 2018Article
- Platelet Hyperactivity inAdvances in wound care · 2016Article
- Platelet membrane variations and their effects on δ-granule secretion kinetics and aggregation spreading among different species.Biochimica et biophysica acta · 2015Article
- Equid herpesvirus type 1 activates platelets.PloS one · 2015Article
- Platelets: still a therapeutical target for haemostatic disorders.International journal of molecular sciences · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Platelets contain an invaginated, tubular membranous structure called the surface-connected open canalicular system (SCCS or OCS), which is contiguous with the plasma membrane and serves as a site for granule fusion and as a reservoir of membrane for platelet spreading. According to ultrastructural studies, platelets from some species lack OCS. In an attempt to correlate biochemical and functional attributes with the presence of an OCS, platelets from human, mouse and dog (OCS(+)), and from cow, camel and horse (OCS(-)) were analysed for differential protein expression and aggregation in response to thrombin. Among the 18 different cytoskeletal and regulatory proteins examined, five (Rac1, RhoA, Ras, calmodulin and Src) were expressed at higher levels in OCS(+) platelets (p < 0.05). Given the role of Arf6 in the formation of tubular invaginations in nucleated cells, the levels of Arf6-GTP were analysed in OCS(+) and OCS(-) platelets. There was no significant correlation between the presence of OCS and total Arf6 or Arf6-GTP levels. Comparison of platelet aggregation between different species suggests that OCS(-) platelets have delayed responses. This comparison of platelets from six different species, which differ in their OCS, shows the differential expression of known signaling components and foreshadows future studies focusing on OCS formation and function.
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Registered trials
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