ArticleOrganic letters2010
A concise, phosphate-mediated approach to the total synthesis of (-)-tetrahydrolipstatin.
Article in Organic letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Decoding the Penicillin-Binding Proteins with Activity-Based Probes.Accounts of chemical research · 2025Review
- Chemical tools for selective activity profiling of bacterial penicillin-binding proteins.Methods in enzymology · 2020Article
- Stereochemical Structure Activity Relationship Studies (S-SAR) of Tetrahydrolipstatin.ACS medicinal chemistry letters · 2018Article
- Novel Electrophilic Scaffold for Imaging of Essential Penicillin-Binding Proteins in Streptococcus pneumoniae.ACS chemical biology · 2017Article
- Synthesis of the C9-C25 Subunit of Spirastrellolide B.Organic letters · 2016Article
- Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Total Synthesis of Cryptocaryol A by Enantioselective Iridium-Catalyzed Alcohol C-H Allylation.Angewandte Chemie (International ed. in English) · 2016Article
- Phosphate Tether-Mediated Ring-Closing Metathesis for the Generation of P-Stereogenic, Z-Configured Bicyclo[7.3.1]- and Bicyclo[8.3.1]phosphates.The Journal of organic chemistry · 2016Article
- A Pot-Economical Approach to the Total Synthesis of Sch-725674.Organic letters · 2016Article
- Phosphate Tether-Mediated Ring-Closing Metathesis for the Generation of Medium to Large,Tetrahedron · 2015Article
- Synthetic Studies to Lyngbouilloside: A Phosphate Tether-Mediated Synthesis of the Macrolactone Core.Tetrahedron letters · 2015Article
- Total synthesis of tetrahydrolipstatin and stereoisomers via a highly regio- and diastereoselective carbonylation of epoxyhomoallylic alcohols.Journal of the American Chemical Society · 2014Article
- An efficient, modular approach for the synthesis of (+)-strictifolione and a related natural product.Organic letters · 2014Article
- A modular phosphate tether-mediated divergent strategy to complex polyols.Beilstein journal of organic chemistry · 2014Article
- Phosphate-tether-mediated ring-closing metathesis for the preparation of complex 1,3-anti-diol-containing subunits.Chemistry (Weinheim an der Bergstrasse, Germany) · 2013Article
- A phosphate tether-mediated, one-pot, sequential ring-closing metathesis/cross-metathesis/chemoselective hydrogenation protocol.Organic letters · 2012Article
- Intramolecular monomer-on-monomer (MoM) Mitsunobu cyclization for the synthesis of benzofused thiadiazepine-dioxides.Chemical communications (Cambridge, England) · 2011Article
- Total synthesis of dolabelide C: a phosphate-mediated approach.The Journal of organic chemistry · 2011Article
- Phosphate tether-mediated approach to the formal total synthesis of (-)-salicylihalamides A and B.The Journal of organic chemistry · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
An efficient synthesis of (-)-tetrahydrolipstatin (THL) is reported. This method takes advantage of a phosphate tether-mediated, one-pot, sequential RCM/CM/hydrogenation protocol to deliver THL in eight total steps from a readily prepared (S,S)-triene. The strategy incorporates selective cross-metathesis, regioselective hydrogenation, regio- and diastereoselective cuprate addition, and Mitsunobu inversion for installation of the C5 formamide ester subunit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.