ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2010
Conservative and surgical treatment of chronic anal fissure: prospective longer term results.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Botulinum toxin and anal fissure: efficacy and safety systematic review.International journal of colorectal disease · 2012Pooled it
- The effects of topical application of metronidazole for treatment of chronic anal fissure: A randomized, controlled pilot study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Trial
- Combined Tribenoside/Lidocaine Rectal Cream (Procto-GlyvenolPharmaceuticals (Basel, Switzerland) · 2026Article
- Injection of botulinum toxin significantly increases efficiency of fissurectomy in the treatment of chronic anal fissures.International journal of colorectal disease · 2022Article
- Botulinum toxin associated with fissurectomy and anoplasty for hypertonic chronic anal fissure: A case-control study.World journal of clinical cases · 2021Article
- Fisurectomy and anoplasty with botulinum toxin injection in patients with chronic anal posterior fissure with hypertonia: a long-term evaluation.Updates in surgery · 2021Article
- Therapeutic properties of botulinum toxin on chronic anal fissure treatment and the patient factors role.Journal of family medicine and primary care · 2020Article
- Long-term outcomes of Botulinum toxin in the treatment of chronic anal fissure: 5 years of follow-up.United European gastroenterology journal · 2017Article
- Long term outcomes after lateral anal sphincterotomy for anal fissure: a retrospective cohort study.Surgery today · 2014Article
- Common anorectal disorders.Gastroenterology & hepatology · 2014Article
- Medical and surgical treatment of haemorrhoids and anal fissure in Crohn's disease: a critical appraisal.BMC gastroenterology · 2013Article
- Effect of chronic anal fissure components on isosorbide dinitrate treatment.World journal of surgery · 2012Article
- Advancement flap in the management of chronic anal fissure: a prospective study.Updates in surgery · 2012Article
- Identifying the best therapy for chronic anal fissure.World journal of gastrointestinal pharmacology and therapeutics · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this prospective study was to assess the efficacy of different medical treatments and surgery in the treatment of chronic anal fissure (CAF). PATIENTS AND
methodsFrom January 2004 to March 2009, 311 patients with typical CAF completed the study. All patients were initially treated with 0.2% nitroglycerin ointment (GTN) or anal dilators (DIL) for 8 weeks. If no improvement was observed after 8 weeks, the patients were assigned to the other treatment or a combination of the two. Persisting symptoms after 12 weeks or recurrence were indications for either botulinum toxin injection into the internal sphincter and fissurectomy or lateral internal sphincterotomy (LIS). During the follow-up (29 +/- 16 months), healing rates, symptoms, incontinence scores, and therapy adverse effects were prospectively recorded.
resultsOverall healing rates were 64.6% and 94% after GTN/DIL or BTX/LIS. Healing rate after GTN or DIL after 12 weeks course were 54.5% and 61.5%, respectively. Fifty-four patients (17.4%) responded to further medical therapy. One hundred two patients (32.8%) underwent BTX or LIS. Healing rate after BTX was 83.3% and overall healing after LIS group was 98.7% with no definitive incontinence.
conclusionIn conclusion, although LIS is far more effective than medical treatments, BTX injection/fissurectomy as first line treatment may significantly increase the healing rate while avoiding any risk of incontinence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.