ReviewMolecular neurobiology2010
Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease.
Review in Molecular neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Overcoming Oxidative Stress in Parkinson's Disease: NADPH Oxidase 4 (NOX4) as a Potential Therapeutic Target.Antioxidants (Basel, Switzerland) · 2026Review
- Exosomal Dynamics and Brain Redox Imbalance: Implications in Alzheimer's Disease Pathology and Diagnosis.Antioxidants (Basel, Switzerland) · 2024Review
- Blackberry-Loaded AgNPs Attenuate Hepatic Ischemia/Reperfusion Injury via PI3K/Akt/mTOR Pathway.Metabolites · 2023Article
- Renal tubular injury induced by glyphosate combined with hard water: the role of cytosolic phospholipase A2.Annals of translational medicine · 2021Article
- Potential Role of Fluoride in the Etiopathogenesis of Alzheimer's Disease.International journal of molecular sciences · 2018Review
- Analyzing Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Aging and Vascular Amyloid Pathology.Frontiers in immunology · 2017Article
- Imaging hydrogen peroxide in Alzheimer's disease via cascade signal amplification.Scientific reports · 2016Article
- P2Y receptors in Alzheimer's disease.Biology of the cell · 2015Review
- Characterization of the expression and inflammatory activity of NADPH oxidase after spinal cord injury.Free radical research · 2014Article
- New insights on NOX enzymes in the central nervous system.Antioxidants & redox signaling · 2014Review
- The role of secretory phospholipase A₂ in the central nervous system and neurological diseases.Molecular neurobiology · 2014Review
- Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease.Current neuropharmacology · 2014Article
- Caffeic Acid phenethyl ester: consequences of its hydrophobicity in the oxidative functions and cytokine release by leukocytes.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury.Journal of neuroinflammation · 2013Article
- Antioxidant treatment strategies for hyperphenylalaninemia.Metabolic brain disease · 2013Review
- Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases.Experimental neurology · 2012Review
- Integrating cytosolic phospholipase A₂ with oxidative/nitrosative signaling pathways in neurons: a novel therapeutic strategy for AD.Molecular neurobiology · 2012Review
- Targeting NOX enzymes in the central nervous system: therapeutic opportunities.Cellular and molecular life sciences : CMLS · 2012Review
- NADPH oxidases as therapeutic targets in ischemic stroke.Cellular and molecular life sciences : CMLS · 2012Review
- The neuroprotective effects of apocynin.Frontiers in bioscience (Elite edition) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Alzheimer's disease (AD) is marked by an increase in the production of extracellular beta amyloid plaques and intracellular neurofibrillary tangles associated with a decline in brain function. Increases in oxidative stress are regarded as an early sign of AD pathophysiology, although the source of reactive oxygen species (ROS) and the mechanism(s) whereby beta amyloid peptides (Abeta) impact oxidative stress have not been adequately investigated. Recent studies provide strong evidence for the involvement of NADPH oxidase and its downstream oxidative signaling pathways in the toxic effects elicited by Abeta. ROS produced by NADPH oxidase activate multiple signaling pathways leading to neuronal excitotoxicity and glial cell-mediated inflammation. This review describes recent studies demonstrating the neurotoxic effects of Abeta in conjunction with ROS produced by NADPH oxidase and the downstream pathways leading to activation of cytosolic phospholipase A(2) (PLA(2)) and secretory PLA(2). In addition, this review also describes recent studies using botanical antioxidants to protect against oxidative damage associated with AD. Investigating the metabolic and signaling pathways involving Abeta NADPH oxidase and PLA(2) can help understand the mechanisms underlying the neurodegenerative effects of oxidative stress in AD. This information should provide new therapeutic approaches for prevention of this debilitating disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.