ArticleJournal of molecular neuroscience : MN2010
The expression of neuroepithelial cell fate determinants in rat spinal cord development.
Article in Journal of molecular neuroscience : MN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Endogenous proliferation after spinal cord injury in animal models.Stem cells international · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lineage specification is tightly regulated by a unique combination of extrinsic and intrinsic cues, but exactly how these cues coordinate the timing and position of cell differentiation during spinal cord development needs further investigation. Notch signaling has major roles in lineage specification. Recent evidence also indicates that the combination of transcription factors of the basic helix-loop-helix (Hes3, Hes5) and homeodomain (Pax6) families establish molecular codes that determine both the timing and position of neurons and glia. The precise expression patterns of these genes in vivo in the developing spinal cord from E13 to E18 are not fully known. In this study, the spatial and temporal expression patterns of these genes have been investigated. RT-PCR studies reveal the differential expression of these genes. The dynamic changes detected in the expression of these molecules have an important role in spinal cord cell lineage specification. Moreover, this study clarifies their in vivo expression during spinal cord development, and the expression patterns observed shed light on the generation of the rostro-caudal gradient of development. By understanding how neural stem cells are regulated in spinal cord development in vivo, we may gain insight of relevance to cell replacement strategies to treat spinal cord injuries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.