ArticleObesity surgery2010
The relationships between IGF-1 and CRP, NO, leptin, and adiponectin during weight loss in the morbidly obese.
Article in Obesity surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Association between visceral adiposity index and risk of prediabetes: A meta-analysis of observational studies.Journal of diabetes investigation · 2022Pooled it
- Surgery for Obesity and Weight-Related Diseases Changes the Inflammatory Profile in Women with Severe Obesity: a Randomized Controlled Clinical Trial.Obesity surgery · 2021Trial
- Systemic Inflammation in Severe Obese Patients Undergoing Surgery for Obesity and Weight-Related Diseases.Obesity surgery · 2018Trial
- Metabolic responses to exogenous ghrelin in obesity and early after Roux-en-Y gastric bypass in humans.Diabetes, obesity & metabolism · 2017Trial
- The effects of an amino acid supplement on glucose homeostasis, inflammatory markers, and incretins after laparoscopic gastric bypass.Journal of the American College of Surgeons · 2011Trial
- Greater Concentrations of IGF Binding Protein-2 after Bariatric Surgery Compared with Diet.Journal of the Endocrine Society · 2026Article
- The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment.Journal of the American College of Cardiology · 2025Review
- Analysis of the adiponectin paradox in healthy older people.Journal of cachexia, sarcopenia and muscle · 2023Article
- Leptin signaling and leptin resistance.Medical review (2021) · 2022Review
- Article
- Effects of gastric sleeve surgery on the serum levels of GH, IGF-1 and IGF-binding protein 2 in healthy obese patients.BMC gastroenterology · 2020Article
- Anti-Obesity Effect of Extract fromFoods (Basel, Switzerland) · 2019Article
- The effect of weight change over a 2-year period on inflammatory status in postmenopausal women.European journal of clinical nutrition · 2018Article
- A Functional Interplay between IGF-1 and Adiponectin.International journal of molecular sciences · 2017Review
- Hepatic CD36 downregulation parallels steatosis improvement in morbidly obese undergoing bariatric surgery.International journal of obesity (2005) · 2017Article
- The IGF-Axis and Diabetic Retinopathy Before and After Gastric Bypass Surgery.Obesity surgery · 2017Article
- Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese.BBA clinical · 2016Article
- Monitoring of Diabetic Retinopathy in relation to Bariatric Surgery: a Prospective Observational Study.Obesity surgery · 2016Observational
- Leptin augments coronary vasoconstriction and smooth muscle proliferation via a Rho-kinase-dependent pathway.Basic research in cardiology · 2016Article
- Morbidly "Healthy" Obese Are Not Metabolically Healthy but Less Metabolically Imbalanced Than Those with Type 2 Diabetes or Dyslipidemia.Obesity surgery · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between C-reactive protein (CRP), nitric oxide (NO), leptin, adiponectin, and insulin growth factor 1 (IGF-1) is poorly defined in morbidly obese patients before and after gastric bypass and, in some cases, is controversial.
methodsWe examined the plasma of 34 morbidly obese patients before and 1, 6, and 12 months after Roux-en-Y gastric bypass surgery.
resultsObese people had more CRP (21.3 +/- 1.8 microg/ml) and leptin (36.9 +/- 4.0 ng/ml) than those in the control group (nonobese people: CRP = 6.9 +/- 0.9 microg/ml, p < 0.0001; leptin = 7.5 +/- 0.4 ng/ml, p < 0.0001). However, they had less NO (30.4 +/- 2.7 nmol/ml), IGF-1 (77.5 +/- 6.6 ng/ml), and adiponectin (11.1 +/- 1.0 microg/ml) than those in the control group (NO = 45.8 +/- 3.9 nmol/ml, p = 0.0059; IGF-1 = 202.0 +/- 12.0 ng/ml, p < 0.0001; adiponectin = 18.0 +/- 2.0 microg/ml, p < 0.0001). During weight loss, the amount of CRP and leptin decreased until they reached the nonobese values, but the level of NO remained lower than in nonobese people, even 1 year after surgery. The linear regression slopes were negative and very significant for leptin (p = 0.0005) and CRP (p = 0.0018) but were less significant for NO (p = 0.0221). IGF-1 displayed a very good linear regression (both negative and significant) with some anthropometric parameters, including body mass index (p = 0.0025), total fat (p = 0.0177), and the percentage of fat (p < 0.0001).
conclusionFor the first time, we report the relationship between IGF-1 and CRP, NO, leptin, and adiponectin. For all these parameters, the best and most widely demonstrated improvements in comorbidities before and during weight loss in morbid obesity were associated with CRP and leptin.
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