ArticlePediatric nephrology (Berlin, Germany)2010
Primary focal segmental glomerulosclerosis in Egyptian children: a 10-year single-centre experience.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Association of histologic variants in FSGS clinical trial with presenting features and outcomes.Clinical journal of the American Society of Nephrology : CJASN · 2013Trial
- Kidney outcomes in children with primary focal segmental glomerulosclerosis from a low- and middle- income country.Pediatric nephrology (Berlin, Germany) · 2024Article
- Predictors of long-term outcomes in pediatric focal segmental glomerulosclerosis.Journal of nephrology · 2023Article
- Primary focal segmental glomerulosclerosis in children: epidemiology, clinical presentation and prognosis.La Tunisie medicale · 2023Article
- Efficacy and Safety of Immunosuppressive Therapy in Primary Focal Segmental Glomerulosclerosis: A Systematic Review and Meta-analysis.Kidney medicine · 2022Article
- Prevalence rates of histopathologic subtypes associated with steroid resistance in childhood nephrotic syndrome in Sub-Saharan Africa: a systematic review.International journal of nephrology and renovascular disease · 2019Article
- Collapsing glomerulopathy, the Saudi Arabian scenario. A study of 31 cases and a review of literature.Saudi medical journal · 2017Review
- A predictive model of progressive chronic kidney disease in idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2015Article
- Pathological profile of biopsied Egyptian children with primary nephrotic syndrome: 15-year single center experience.Journal of nephrology · 2014Article
- Frequency and clinicopathological correlations of histopathological variants of pediatric idiopathic focal segmental glomerulosclerosis.Indian journal of nephrology · 2014Article
- Article
- NPHS2 mutations.Indian journal of pediatrics · 2008Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary focal segmental glomerulosclerosis (FSGS) in children accounts for 7-20% of all cases of idiopathic nephrotic syndrome (NS). To evaluate the clinical course of children with primary FSGS, the records of 72 patients with biopsy-proven FSGS admitted between 1995 and 2008 were retrospectively analysed. Forty-eight patients were male (66.7%). The mean age at presentation was 76.5 +/- 54 (range 12-192) months. The mean duration of follow-up was 76.3 +/- 42 (range 9-156) months. Seventeen patients (23.6%) presented with gross haematuria at initial presentation, 15 (20.8%) presented with hypertension and 10 patients (14%) presented with chronic renal insufficiency (CRI). The initial response to oral prednisolone was steroid resistance in 63 patients (87.5%) and steroid dependence in 4 patients (5%), while 5 patients (6.9%) were biopsied from the start because of atypical presentation. According to pathological classification, there were the tip variant (2%), collapsing variant (6%), perihilar variant (7%) and NOS (not otherwise specified; 85%). At the last clinical visit, 12 patients (16.7%) were in complete remission and 11 (15.3%) had progressed to CRI. Renal survival rates at 5 and 10 years were 93% and 68%, respectively. In conclusion, in this study we had a low percentage of FSGS, and fewer patients presenting with gross haematuria and hypertension compared with previous reports. In addition, the short-term overall renal survival seems to be better in our cohort.
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