ArticleParasitology research2010
The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection.
Article in Parasitology research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Effects of Selenium treatment on cardiac function in Chagas heart disease: Results from the STCC randomized Trial.EClinicalMedicine · 2021Article
- Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale.PLoS pathogens · 2021Article
- Selenium Derivatives as Promising Therapy for Chagas Disease:ACS infectious diseases · 2021Article
- Correlation between intestinal BMP2, IFNγ, and neural death in experimental infection with Trypanosoma cruzi.PloS one · 2021Article
- Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response.Journal of biomedical optics · 2020Article
- Dual and Opposite Roles of Reactive Oxygen Species (ROS) in Chagas Disease: Beneficial on the Pathogen and Harmful on the Host.Oxidative medicine and cellular longevity · 2020Review
- Selenium and selenoproteins in prostanoid metabolism and immunity.Critical reviews in biochemistry and molecular biology · 2019Review
- Selenoprotein Expression in Macrophages Is Critical for Optimal Clearance of Parasitic Helminth Nippostrongylus brasiliensis.The Journal of biological chemistry · 2016Article
- Article
- Imaging of small-animal models of infectious diseases.The American journal of pathology · 2013Review
- Would selenium supplementation aid in therapy for Chagas disease?Trends in parasitology · 2011Article
- Advances in imaging of animal models of Chagas disease.Advances in parasitology · 2011Article
- Nutritional Status Driving Infection by Trypanosoma cruzi: Lessons from Experimental Animals.Journal of tropical medicine · 2011Article
- Trypanosoma cruzi infection: do distinct populations cause intestinal motility alteration?Parasitology research · 2010Article
- Imaging the Gastrointestinal Tract of Small Animals.Journal of neuroparasitology · 2010Article
- Chagas heart disease: report on recent developments.Cardiology in reviewReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Infection with Trypanosoma cruzi causes megasyndromes of the gastrointestinal (GI) tract in humans and animals. In the present study, we employed magnetic resonance imaging to non-invasively monitor the effect of selenium supplementation on alterations in the GI tract of T. cruzi-infected mice. CD1 mice infected with T. cruzi (Brazil strain) exhibited dilatation of the intestines similar to that we recently reported in infected C57Bl/6 mice. The average intestine lumen diameter increased by 65% and the increase was reduced to 29% in mice supplemented with 2 ppm selenium in the drinking water. When supplemented with 3 ppm selenium in chow the lumen diameter was also significantly reduced although the difference between the infected and infected supplemented mice was smaller. Intestinal motility in infected mice fed with selenium-enriched chow was increased compared with infected mice fed with normal unsupplemented chow and was not significantly different from intestinal motility in uninfected mice. We suggest that Se may be used to modulate the inflammatory, immunological, and/or antioxidant responses involved in intestinal disturbances caused by T. cruzi infection.
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Registered trials
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