ArticlePloS one2010
The genome of Streptococcus mitis B6--what is a commensal?
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed.
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- Chromosomal Curing Drives an Arms Race Between Bacterial Transformation and Prophage.Molecular biology and evolution · 2025Article
- Encapsulation of Disease-Causing and Commensal Mitis Group Non-Pneumococcal Streptococci.Pathogens (Basel, Switzerland) · 2025Article
- Analysis of Clinical Characteristics and Antimicrobial Resistance in 249 Isolates ofPolish journal of microbiology · 2025Article
- Genomic and functional insights into commensal streptococci with anti-pneumococcal activity.BMC genomics · 2025Article
- Naturally competent bacteria and their genetic parasites-a battle for control over horizontal gene transfer?FEMS microbiology reviews · 2025Review
- Probiotic Effect ofPathogens (Basel, Switzerland) · 2024Article
- Molecular characterization of theFrontiers in veterinary science · 2024Article
- Review
- An Isolate ofNutrients · 2023Article
- Identification and characterization of a novel aminoglycosideFrontiers in microbiology · 2023Article
- Analysis of phylogenetic markers for classification of a hydrogen peroxide producing Streptococcus oralis isolated from saliva by a newly devised differential medium.Journal of microbiology (Seoul, Korea) · 2022Article
- A high-quality reference genome for the fish pathogenMicrobial genomics · 2022Article
- The Role of SilX in Bacteriocin Production ofFrontiers in microbiology · 2022Article
- Streptococcal Infections in Marine Mammals.Microorganisms · 2021Review
- Tandem sialoglycan-binding modules in aThe Journal of biological chemistry · 2020Article
- Autolysin (lytA) recombinant protein: a potential target for developing vaccines against pneumococcal infections.Clinical and experimental vaccine research · 2020Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus mitis is the closest relative of the major human pathogen S. pneumoniae. The 2,15 Mb sequence of the Streptococcus mitis B6 chromosome, an unusually high-level beta-lactam resistant and multiple antibiotic resistant strain, has now been determined to encode 2100 genes. The accessory genome is estimated to represent over 40%, including 75 mostly novel transposases and IS, the prophage phiB6 and another seven phage related regions. Tetracycline resistance mediated by Tn5801, and an unusual and large gene cluster containing three aminoglycoside resistance determinants have not been described in other Streptococcus spp. Comparative genomic analyses including hybridization experiments on a S. mitis B6 specific microarray reveal that individual S. mitis strains are almost as distantly related to the B6 strain as S. pneumoniae. Both species share a core of over 900 genes. Most proteins described as pneumococcal virulence factors are present in S. mitis B6, but the three choline binding proteins PcpA, PspA and PspC, and three gene clusters containing the hyaluronidase gene, ply and lytA, and the capsular genes are absent in S. mitis B6 and other S. mitis as well and confirm their importance for the pathogenetic potential of S. pneumoniae. Despite the close relatedness between the two species, the S. mitis B6 genome reveals a striking X-alignment when compared with S. pneumoniae.
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