ArticlePLoS genetics2010
Cheating by exploitation of developmental prestalk patterning in Dictyostelium discoideum.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- Testing the coordination hypothesis: incompatibilities in aggregative development of an experimentally evolved social amoeba.Evolution letters · 2025Article
- Simulated Heat Waves Affect Cell Fate and Fitness in the Social Amoeba Dictyostelium discoideum.Microbial ecology · 2025Article
- In the social amoebaPeerJ · 2024Article
- Parallel evolution of the G protein-coupled receptor GrlG and the loss of fruiting body formation in the social amoeba Dictyostelium discoideum evolved under low relatedness.G3 (Bethesda, Md.) · 2023Article
- Reduced social function in experimentally evolvedProceedings. Biological sciences · 2023Article
- Cellular allorecognition and its roles in Dictyostelium development and social evolution.The International journal of developmental biology · 2019Review
- Identification of distinct biological functions for four 3'-5' RNA polymerases.Nucleic acids research · 2016Article
- Sociogenomics of self vs. non-self cooperation during development of Dictyostelium discoideum.BMC genomics · 2014Article
- A new social gene in Dictyostelium discoideum, chtB.BMC evolutionary biology · 2013Article
- ABC transporters in Dictyostelium discoideum development.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cooperative developmental system of the social amoeba Dictyostelium discoideum is susceptible to exploitation by cheaters-strains that make more than their fair share of spores in chimerae. Laboratory screens in Dictyostelium have shown that the genetic potential for facultative cheating is high, and field surveys have shown that cheaters are abundant in nature, but the cheating mechanisms are largely unknown. Here we describe cheater C (chtC), a strong facultative cheater mutant that cheats by affecting prestalk differentiation. The chtC gene is developmentally regulated and its mRNA becomes stalk-enriched at the end of development. chtC mutants are defective in maintaining the prestalk cell fate as some of their prestalk cells transdifferentiate into prespore cells, but that defect does not affect gross developmental morphology or sporulation efficiency. In chimerae between wild-type and chtC mutant cells, the wild-type cells preferentially give rise to prestalk cells, and the chtC mutants increase their representation in the spore mass. Mixing chtC mutants with other cell-type proportioning mutants revealed that the cheating is directly related to the prestalk-differentiation propensity of the victim. These findings illustrate that a cheater can victimize cooperative strains by exploiting an established developmental pathway.
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