ArticlePLoS genetics2010
Population genomics of parallel adaptation in threespine stickleback using sequenced RAD tags.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 562 papers, 2 of them syntheses that pooled it.
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Who cites it
562 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A macrogenetic analysis of isolation mechanisms shaping genetic divergence in mammals.The Journal of heredity · 2026Pooled it
- Shortcomings of Phylogenetic Studies on Recent Radiated Insular Groups: A Meta-Analysis Using Cabo Verde Biodiversity.International journal of molecular sciences · 2019Pooled it
- Enhancing detection of polygenic adaptation: a comparative study of machine learning and statistical approaches using simulated evolve-and-resequence data.BMC genomics · 2026Article
- Historical and contemporary butterfly genomes reveal genetic erosion in response to land-use intensification.iScience · 2026Article
- Assessing differences among elasmobranch nurseries to aid conservation based on a genomics framework.Conservation biology : the journal of the Society for Conservation Biology · 2026Article
- Parallel adaptation to geothermally-warmed habitats due to common structural variation and functional developmental pathways.Nature communications · 2026Article
- Genomic Patterns of Parallel Divergence Across Demographically Heterogeneous Stickleback Populations in Eastern Canada.Genome biology and evolution · 2026Article
- Multiple modes of selection underlie repeated and human-mediated adaptation in a formerly migratory fish.Molecular biology and evolution · 2026Article
- The genomic architecture of local adaptation in two connected populations of three-spined stickleback.G3 (Bethesda, Md.) · 2026Article
- Genetic Divergence in the Absence of Strong Ecological Differences Between Coexisting White and Common Atlantic Marine Stickleback.Ecology and evolution · 2026Article
- Rapid and repeated evolution of myosin copy number in threespine stickleback.Current biology : CB · 2026Article
- Scaling up orphan crop research: genebank genetics highlight geographic structure in cultivated cowpea from 10 617 global accessions.The Plant journal : for cell and molecular biology · 2026Article
- High-quality genome ofPlant diversity · 2026Article
- Patterns of Interploidy Admixture in Polyploid Complexes: Insights From Thymus Sect. Mastichina (Lamiaceae).Molecular ecology · 2026Article
- Article
- Genomic characterization of a global Corylus avellana L. collection: insights into hazelnut ancestry and genetic determinants of production traits.BMC plant biology · 2025Article
- Rapid and repeated evolution of myosin copy number in threespine stickleback.bioRxiv : the preprint server for biology · 2025Article
- Genome-wide characterization and seasonal modulation of Hsp60 expression in juvenile Hilsa Shad across distinct upstream habitats.Journal, genetic engineering & biotechnology · 2025Article
- A Shift to Metapopulation Genetic Management for Persistence of a Species Threatened by Fragmentation: The Case of an Endangered Australian Freshwater Fish.Molecular ecology · 2025Article
- Human Impacts on Great Lakes Walleye Sander vitreus Structure, Diversity and Local Adaptation.Molecular ecology · 2025Article
502 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Next-generation sequencing technology provides novel opportunities for gathering genome-scale sequence data in natural populations, laying the empirical foundation for the evolving field of population genomics. Here we conducted a genome scan of nucleotide diversity and differentiation in natural populations of threespine stickleback (Gasterosteus aculeatus). We used Illumina-sequenced RAD tags to identify and type over 45,000 single nucleotide polymorphisms (SNPs) in each of 100 individuals from two oceanic and three freshwater populations. Overall estimates of genetic diversity and differentiation among populations confirm the biogeographic hypothesis that large panmictic oceanic populations have repeatedly given rise to phenotypically divergent freshwater populations. Genomic regions exhibiting signatures of both balancing and divergent selection were remarkably consistent across multiple, independently derived populations, indicating that replicate parallel phenotypic evolution in stickleback may be occurring through extensive, parallel genetic evolution at a genome-wide scale. Some of these genomic regions co-localize with previously identified QTL for stickleback phenotypic variation identified using laboratory mapping crosses. In addition, we have identified several novel regions showing parallel differentiation across independent populations. Annotation of these regions revealed numerous genes that are candidates for stickleback phenotypic evolution and will form the basis of future genetic analyses in this and other organisms. This study represents the first high-density SNP-based genome scan of genetic diversity and differentiation for populations of threespine stickleback in the wild. These data illustrate the complementary nature of laboratory crosses and population genomic scans by confirming the adaptive significance of previously identified genomic regions, elucidating the particular evolutionary and demographic history of such regions in natural populations, and identifying new genomic regions and candidate genes of evolutionary significance.
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