ArticlePLoS computational biology2010
Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 58 citations in OpenAlex.
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- Force-dependent focal adhesion assembly and disassembly: A computational study.PLoS computational biology · 2023Article
- On multistability and constitutive relations of cell motion on fibronectin lanes.Biophysical journal · 2023Article
- Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling.Biophysical journal · 2022Article
- Exploring the influence of cytosolic and membrane FAK activation on YAP/TAZ nuclear translocation.Biophysical journal · 2021Article
- Discrete mechanical model of lamellipodial actin network implements molecular clutch mechanism and generates arcs and microspikes.PLoS computational biology · 2021Article
- Towards understanding the messengers of extracellular space: Computational models of outside-in integrin reaction networks.Computational and structural biotechnology journal · 2021Review
- Cell-substrate mechanics guide collective cell migration through intercellular adhesion: a dynamic finite element cellular model.Biomechanics and modeling in mechanobiology · 2020Article
- Dynamics of Mechanosensitive Nascent Adhesion Formation.Biophysical journal · 2019Article
- Rac activation is key to cell motility and directionality: An experimental and modelling investigation.Computational and structural biotechnology journal · 2019Article
- Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis-modulating integrin-binding peptides.Journal of theoretical biology · 2018Article
- Paxillin phosphorylation at serine 273 and its effects on Rac, Rho and adhesion dynamics.PLoS computational biology · 2018Article
- Axon growth regulation by a bistable molecular switch.Proceedings. Biological sciences · 2018Article
- Multivalent Binding of a Ligand-Coated Particle: Role of Shape, Size, and Ligand Heterogeneity.Biophysical journal · 2018Article
- Cell protrusion and retraction driven by fluctuations in actin polymerization: A two-dimensional model.Cytoskeleton (Hoboken, N.J.) · 2017Article
- Adhesion-Dependent Wave Generation in Crawling Cells.Current biology : CB · 2017Article
- Spatial and temporal coordination of traction forces in one-dimensional cell migration.Cell adhesion & migration · 2016Article
- A Computational Model of YAP/TAZ Mechanosensing.Biophysical journal · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Productive cell migration requires the spatiotemporal coordination of cell adhesion, membrane protrusion, and actomyosin-mediated contraction. Integrins, engaged by the extracellular matrix (ECM), nucleate the formation of adhesive contacts at the cell's leading edge(s), and maturation of nascent adhesions to form stable focal adhesions constitutes a functional switch between protrusive and contractile activities. To shed additional light on the coupling between integrin-mediated adhesion and membrane protrusion, we have formulated a quantitative model of leading edge dynamics combining mechanistic and phenomenological elements and studied its features through classical bifurcation analysis and stochastic simulation. The model describes in mathematical terms the feedback loops driving, on the one hand, Rac-mediated membrane protrusion and rapid turnover of nascent adhesions, and on the other, myosin-dependent maturation of adhesions that inhibit protrusion at high ECM density. Our results show that the qualitative behavior of the model is most sensitive to parameters characterizing the influence of stable adhesions and myosin. The major predictions of the model, which we subsequently confirmed, are that persistent leading edge protrusion is optimal at an intermediate ECM density, whereas depletion of myosin IIA relieves the repression of protrusion at higher ECM density.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.