ArticlePloS one2010
Antimicrobial resistance, class 1 integrons, and genomic island 1 in Salmonella isolates from Vietnam.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Animal-human interfaces and emerging zoonoses:Frontiers in veterinary science · 2026Article
- A Highly Drug-ResistantIndian journal of microbiology · 2025Review
- The gut microbiome: an emerging epicenter of antimicrobial resistance?Frontiers in microbiology · 2025Review
- Non-typhoidalJAC-antimicrobial resistance · 2024Review
- A review and meta-analysis of non-typhoidalOne health (Amsterdam, Netherlands) · 2024Review
- Whole-Genome Sequencing Analysis of Non-TyphoidalAntibiotics (Basel, Switzerland) · 2023Article
- A systematic review and meta-analysis of integrated studies on antimicrobial resistance in Vietnam, with a focus onOne health (Amsterdam, Netherlands) · 2022Review
- Multi‑locus sequence and drug resistance analysis of Salmonella infection in children with diarrhea in Guangdong to identify the dominant ST and cause of antibiotic‑resistance.Experimental and therapeutic medicine · 2022Article
- Mobility of antimicrobial resistance across serovars and disease presentations in non-typhoidalMicrobial genomics · 2022Article
- Characterization of non-typhoidal Salmonella isolates from children with acute gastroenteritis, Kolkata, India, during 2000-2016.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Detection and Molecular Identification ofPathogens (Basel, Switzerland) · 2019Article
- Carriage of Class 1 integrons and molecular characterization ofVeterinary world · 2019Article
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- Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidalFrontiers in microbiology · 2018Article
- Antimicrobial Usage and Antimicrobial Resistance in Animal Production in Southeast Asia: A Review.Antibiotics (Basel, Switzerland) · 2016Review
- Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections.Clinical microbiology reviews · 2015Review
- High levels of contamination and antimicrobial-resistant non-typhoidal Salmonella serovars on pig and poultry farms in the Mekong Delta of Vietnam.Epidemiology and infection · 2015Article
- Molecular Detection of Genomic Islands Associated With Class 1 and 2 Integron in Haemophilus influenzae Isolated in Iran.Jundishapur journal of microbiology · 2015Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective was to investigate the phenotypic and genotypic resistance and the horizontal transfer of resistance determinants from Salmonella isolates from humans and animals in Vietnam. METHODOLOGY/PRINCIPAL
findingsThe susceptibility of 297 epidemiologically unrelated non-typhoid Salmonella isolates was investigated by disk diffusion assay. The isolates were screened for the presence of class 1 integrons and Salmonella genomic island 1 by PCR. The potential for the transfer of resistance determinants was investigated by conjugation experiments. Resistance to gentamicin, kanamycin, chloramphenicol, streptomycin, trimethoprim, ampicillin, nalidixic acid, sulphonamides, and tetracycline was found in 13 to 50% of the isolates. Nine distinct integron types were detected in 28% of the isolates belonging to 11 Salmonella serovars including S. Tallahassee. Gene cassettes identified were aadA1, aadA2, aadA5, bla(PSE-1), bla(OXA-30), dfrA1, dfrA12, dfrA17, and sat, as well as open reading frames with unknown functions. Most integrons were located on conjugative plasmids, which can transfer their antimicrobial resistance determinants to Escherichia coli or Salmonella Enteritidis, or with Salmonella Genomic Island 1 or its variants. The resistance gene cluster in serovar Emek identified by PCR mapping and nucleotide sequencing contained SGI1-J3 which is integrated in SGI1 at another position than the majority of SGI1. This is the second report on the insertion of SGI1 at this position. High-level resistance to fluoroquinolones was found in 3 multiresistant S. Typhimurium isolates and was associated with mutations in the gyrA gene leading to the amino acid changes Ser83Phe and Asp87Asn.
conclusionsResistance was common among Vietnamese Salmonella isolates from different sources. Legislation to enforce a more prudent use of antibiotics in both human and veterinary medicine should be implemented by the authorities in Vietnam.
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