Trial reportPloS one2010
Malaria prevention with IPTp during pregnancy reduces neonatal mortality.
Trial report in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00209781 (Effect of Intermittent Preventive Treatment), which is not on this map. Cited by 75 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Intermittent Preventive Treatment (IPTp) With Sulfadoxine-Pyrimethamine Plus Insecticide Treated Nets, Delivered Through Antenatal Clinics for the Prevention of Malaria in Mozambican Pregnant Women
Who cites it
75 citing papers in PubMed, 7 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Mapping the evidence on stillbirth prevention across the reproductive continuum: an umbrella review.BMJ open · 2026Pooled it
- Intermittent preventive treatment regimens for malaria in HIV-positive pregnant women.The Cochrane database of systematic reviews · 2024Pooled it
- Perinatal Mortality in Sub-Saharan Africa: A Meta-Analysis of Demographic and Health Surveys.Annals of global health · 2019Pooled it
- Mefloquine for preventing malaria in pregnant women.The Cochrane database of systematic reviews · 2018Pooled it
- Mefloquine for preventing malaria in pregnant women.The Cochrane database of systematic reviews · 2018Pooled it
- Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no treatment.The Cochrane database of systematic reviews · 2014Pooled it
- Why are IPTp coverage targets so elusive in sub-Saharan Africa? A systematic review of health system barriers.Malaria journal · 2013Pooled it
- Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study.Malaria journal · 2019Trial
- Trial
- Statistical methodology for the evaluation of vaccine efficacy in a phase III multi-centre trial of the RTS, S/AS01 malaria vaccine in African children.Malaria journal · 2011Trial
- Impact of malaria at the end of pregnancy on infant mortality and morbidity.The Journal of infectious diseases · 2011Trial
- Cost-effectiveness of intermittent preventive treatment of malaria in pregnancy in southern Mozambique.PloS one · 2010Trial
- Factors influencing antenatal care utilisation in Madang Province, Papua New Guinea: a qualitative study.BMC pregnancy and childbirth · 2026Article
- Use of insecticide-treated nets (ITN) and intermittent preventive treatment (IPTp) for malaria prevention and its associated factors among pregnant women in Sub-Sahara Africa.Malaria journal · 2026Article
- Immunization strategies to prevent malaria in pregnancy - a multistakeholder workshop.Vaccine · 2026Article
- Article
- Machine learning-based ecological prediction of maternal mortality ratio in malaria-endemic Africa.Frontiers in public health · 2026Article
- Reduction in Asymptomatic falciparum malaria infection amongst schoolchildren in three ecological zones of Ghana between 2017 and 2023.Scientific reports · 2025Article
- Current update on malaria in pregnancy: a systematic review.Tropical diseases, travel medicine and vaccines · 2025Review
- Sub-microscopic Plasmodium falciparum infections and multiple drug resistant single nucleotide polymorphic alleles in pregnant women from southwestern Nigeria.BMC research notes · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the global context of a reduction of under-five mortality, neonatal mortality is an increasingly relevant component of this mortality. Malaria in pregnancy may affect neonatal survival, though no strong evidence exists to support this association.
methodsIn the context of a randomised, placebo-controlled trial of intermittent preventive treatment (IPTp) with sulphadoxine-pyrimethamine (SP) in 1030 Mozambican pregnant women, 997 newborns were followed up until 12 months of age. There were 500 live borns to women who received placebo and 497 to those who received SP.
findingsThere were 58 infant deaths; 60.4% occurred in children born to women who received placebo and 39.6% to women who received IPTp (p = 0.136). There were 25 neonatal deaths; 72% occurred in the placebo group and 28% in the IPTp group (p = 0.041). Of the 20 deaths that occurred in the first week of life, 75% were babies born to women in the placebo group and 25% to those in the IPTp group (p = 0.039). IPTp reduced neonatal mortality by 61.3% (95% CI 7.4%, 83.8%); p = 0.024].
conclusionsMalaria prevention with SP in pregnancy can reduce neonatal mortality. Mechanisms associated with increased malaria infection at the end of pregnancy may explain the excess mortality in the malaria less protected group. Alternatively, SP may have reduced the risk of neonatal infections. These findings are of relevance to promote the implementation of IPTp with SP, and provide insights into the understanding of the pathophysiological mechanisms through which maternal malaria affects fetal and neonatal health.
trial registrationClinicalTrials.gov NCT00209781.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.