ArticlePloS one2010
The Drosophila gene CheB42a is a novel modifier of Deg/ENaC channel function.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Visual recognition of the anteroposterior female body axis drives spatial elements of male courtship in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Evolution of chemosensory tissues and cells across ecologically diverse Drosophilids.Nature communications · 2024Article
- A pleiotropic chemoreceptor facilitates the production and perception of mating pheromones.iScience · 2023Article
- Olfactory systems across mosquito species.Cell and tissue research · 2021Review
- Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor.PLoS biology · 2019Article
- Deciphering the olfactory repertoire of the tiger mosquito Aedes albopictus.BMC genomics · 2017Article
- Regulating Factors in Acid-Sensing Ion Channel 1a Function.Neurochemical research · 2016Review
- Candidate ionotropic taste receptors in the Drosophila larva.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Drosophila Bitter Taste(s).Frontiers in integrative neuroscience · 2015Review
- Feminization of pheromone-sensing neurons affects mating decisions in Drosophila males.Biology open · 2014Article
- Aggression and courtship in Drosophila: pheromonal communication and sex recognition.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Review
- The genetic architecture of degenerin/epithelial sodium channels in Drosophila.G3 (Bethesda, Md.) · 2013Article
- Article
- ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster.PLoS genetics · 2012Article
- Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC).Advances in genetics · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Degenerin/epithelial Na(+) channels (DEG/ENaC) represent a diverse family of voltage-insensitive cation channels whose functions include Na(+) transport across epithelia, mechanosensation, nociception, salt sensing, modification of neurotransmission, and detecting the neurotransmitter FMRFamide. We previously showed that the Drosophila melanogaster Deg/ENaC gene lounge lizard (llz) is co-transcribed in an operon-like locus with another gene of unknown function, CheB42a. Because operons often encode proteins in the same biochemical or physiological pathway, we hypothesized that CHEB42A and LLZ might function together. Consistent with this hypothesis, we found both genes expressed in cells previously implicated in sensory functions during male courtship. Furthermore, when coexpressed, LLZ coprecipitated with CHEB42A, suggesting that the two proteins form a complex. Although LLZ expressed either alone or with CHEB42A did not generate ion channel currents, CHEB42A increased current amplitude of another DEG/ENaC protein whose ligand (protons) is known, acid-sensing ion channel 1a (ASIC1a). We also found that CHEB42A was cleaved to generate a secreted protein, suggesting that CHEB42A may play an important role in the extracellular space. These data suggest that CHEB42A is a modulatory subunit for sensory-related Deg/ENaC signaling. These results are consistent with operon-like transcription of CheB42a and llz and explain the similar contributions of these genes to courtship behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.