Evidence map›Paper›PMID 20195267›Full record

ReviewNature reviews. Cardiology2010

Mechanisms of stress (Takotsubo) cardiomyopathy.

Holger M Nef, Helge Möllmann, Yoshihiro J Akashi, Christian W Hamm

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02897739 (Pathogenesis of Acute Stress Induced), which is not on this map. Cited by 115 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 1 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02897739 completednot on this mapstarted 2015, after this paper: background citation

Pathogenesis of Acute Stress Induced (Tako-tsubo) Cardiomyopathy: Energy Shut-Down or Intense Inflammation? The TERRIFIC Study

Typeobservational_patient_registrySponsorUniversity of AberdeenRan2015 to 2019Enrolled77ConditionsTako-tsubo CardiomyopathyArmsMagnetic resonance imaging, Acute Inflammatory Activation study, PET CT, Psychological assessment
3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 1 synthesis or guideline pooled it, 263 citations in OpenAlex.

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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Holger M NefDepartment of Cardiology, Kerckhoff Heart and Thorax Center, 61231 Bad Nauheim, Germany. h.nef@kerckhoff-fgi.de
Helge Möllmann
Yoshihiro J Akashi
Christian W Hamm
Kerckhoff Klinik · DESt. Marianna University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress cardiomyopathy, also referred to as Takotsubo cardiomyopathy, transient apical ballooning or broken heart syndrome, is a disorder associated with transient left ventricular dysfunction. Symptoms include acute chest pain and dyspnea accompanied by electrocardiographic changes, such as ST-segment elevation and T-wave inversions, minimal elevation of cardiac enzyme levels and transient wall-motion abnormalities in the absence of substantial coronary artery obstruction. Complete recovery of contractile function has been documented in nearly all cases, but the mechanisms of disease remain unclear and the cause has not been established. Coronary artery vasospasm, microcirculation dysfunction, and transient obstruction of the left ventricular outflow tract have been proposed as possible causes of this disorder. An excessive release of catecholamines also seems to have a pivotal role in the development of stress cardiomyopathy. This Review summarizes published data on stress cardiomyopathy, focusing primarily on the most likely causes of this cardiac entity.

Indexed as

Acute DiseaseAnimalsCatecholaminesCoronary VasospasmDisease Models, AnimalHumansMicrocirculationPrevalenceRisk FactorsSarcoplasmic Reticulum Calcium-Transporting ATPasesStress, PsychologicalSympathetic Nervous SystemTakotsubo CardiomyopathyUnited StatesVentricular Dysfunction, LeftVentricular Outflow ObstructionATP2A2 protein, humanCatecholaminesSarcoplasmic Reticulum Calcium-Transporting ATPases

Identifiers

PMID20195267
OpenAlexW1973089655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.