Evidence map›Paper›PMID 20194965›Full record

ArticleGenetics2010

The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors.

Walter Arancio, Maria C Onorati, Giosalba Burgio, Marianna Collesano, Antonia M R Ingrassia, Swonild I Genovese, Manolis Fanto, Davide F V Corona

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Walter ArancioDipartimento di Scienze Biochimiche, Istituto Telethon Dulbecco, Universitá degli Studi di Palermo, Palermo, Italy.
Maria C Onorati
Giosalba Burgio
Marianna Collesano
Antonia M R Ingrassia
Swonild I Genovese
Manolis Fanto
Davide F V Corona
Dulbecco Telethon Institute · ITUniversity of Palermo · ITInstitute of Cell Biology and Neurobiology · IT

Funding

Telethon TCR09002
6 · The paper itself

Abstract

ISWI is an evolutionarily conserved ATP-dependent chromatin remodeling factor playing central roles in DNA replication, RNA transcription, and chromosome organization. The variety of biological functions dependent on ISWI suggests that its activity could be highly regulated. Our group has previously isolated and characterized new cellular activities that positively regulate ISWI in Drosophila melanogaster. To identify factors that antagonize ISWI activity we developed a novel in vivo eye-based assay to screen for genetic suppressors of ISWI. Our screen revealed that ISWI interacts with an evolutionarily conserved network of cellular and nuclear factors that escaped previous genetic and biochemical analyses.

Indexed as

Conserved SequenceEvolution, MolecularAdenosine TriphosphatasesAnimalsBiological AssayCell CycleDrosophila melanogasterDrosophila ProteinsEyeFluorometryGenes, SuppressorGenetic TestingMutationNucleosomesPhenotypeProtein BindingAdenosine TriphosphatasesDrosophila ProteinsISWI proteinNucleosomesTranscription Factors

Identifiers

PMID20194965
PMCPMC2870949
OpenAlexW2037485742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.