Trial reportArchives of general psychiatry2010
A placebo-controlled trial of phenelzine, cognitive behavioral group therapy, and their combination for social anxiety disorder.
Trial report in Archives of general psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 206 citations in OpenAlex.
- Comparative effectiveness of non-pharmacological interventions for social anxiety disorder in adults: a systematic review and meta-analysis.Frontiers in psychology · 2026Pooled it
- The effects of art therapy interventions on anxiety in children and adolescents: A meta-analysis.Clinics (Sao Paulo, Brazil) · 2024Pooled it
- Cognitive behavioral therapy for anxiety and related disorders: A meta-analysis of randomized placebo-controlled trials.Depression and anxiety · 2018Pooled it
- The effectiveness of art therapy for anxiety in adults: A systematic review of randomised and non-randomised controlled trials.PloS one · 2018Pooled it
- Pharmacotherapy for social anxiety disorder (SAnD).The Cochrane database of systematic reviews · 2017Pooled it
- Pooled it
- Work-Related Cognitive Behavioral Therapy for racially and economically diverse unemployed persons with social anxiety: A randomized clinical trial.Journal of anxiety disorders · 2024Trial
- Trial
- Trial
- Trial
- Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data.Cognitive behaviour therapy · 2015Trial
- Work-related CBT versus vocational services as usual for unemployed persons with social anxiety disorder: A randomized controlled pilot trial.Behaviour research and therapy · 2014Trial
- D-cycloserine augmentation of cognitive behavioral group therapy of social anxiety disorder: prognostic and prescriptive variables.Journal of consulting and clinical psychology · 2013Trial
- D-Cycloserine as an augmentation strategy with cognitive-behavioral therapy for social anxiety disorder.The American journal of psychiatry · 2013Trial
- Trial
- Review
- Anxiety and depression in emerging adults: The STAND program as a model of scalable screening and intervention.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Multiple Stakeholder Perspectives of Implementing Work-Related Cognitive Behavioral Therapy (WCBT) in Vocational Service Settings: A Qualitative Exploration of Intervention Acceptability and Sustainability.The journal of behavioral health services & research · 2025Article
- Efficacy of hybrid remote neuropsychological rehabilitation on cognitive complaints in post-therapeutic lower-grade glioma: the FREEDOME randomized study protocol.Frontiers in psychology · 2025Article
- Fostering adolescent engagement in generative AI art therapy: a dual SEM-ANN analysis of emotional.Frontiers in psychology · 2025Article
Corrections and comments
- Commented on by
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
contextMedication and cognitive behavioral treatment are the best-established treatments for social anxiety disorder, yet many individuals remain symptomatic after treatment.
objectiveTo determine whether combined medication and cognitive behavioral treatment is superior to either monotherapy or pill placebo.
designRandomized, double-blind, placebo-controlled trial.
settingResearch clinics at Columbia University and Temple University.
participantsOne hundred twenty-eight individuals with a primary DSM-IV diagnosis of social anxiety disorder.
interventionsCognitive behavioral group therapy (CBGT), phenelzine sulfate, pill placebo, and combined CBGT plus phenelzine.
main outcome measuresLiebowitz Social Anxiety Scale and Clinical Global Impression (CGI) scale scores at weeks 12 and 24.
resultsLinear mixed-effects models showed a specific order of effects, with steepest reductions in Liebowitz Social Anxiety Scale scores for the combined group, followed by the monotherapies, and the least reduction in the placebo group (Williams test = 4.97, P < .01). The CGI response rates in the intention-to-treat sample at week 12 were 9 of 27 (33.3%) (placebo), 16 of 34 (47.1%) (CBGT), 19 of 35 (54.3%) (phenelzine), and 23 of 32 (71.9%) (combined treatment) (chi(2)(1) = 8.76, P < .01). Corresponding remission rates (CGI = 1) were 2 of 27 (7.4%), 3 of 34 (8.8%), 8 of 35 (22.9%), and 15 of 32 (46.9%) (chi(2)(1) = 15.92, P < .01). At week 24, response rates were 9 of 27 (33.3%), 18 of 34 (52.9%), 17 of 35 (48.6%), and 25 of 32 (78.1%) (chi(2)(1) = 12.02, P = .001). Remission rates were 4 of 27 (14.8%), 8 of 34 (23.5%), 9 of 35 (25.7%), and 17 of 32 (53.1%) (chi(2)(1) = 10.72, P = .001).
conclusionCombined phenelzine and CBGT treatment is superior to either treatment alone and to placebo on dimensional measures and on rates of response and remission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.