ArticleProceedings of the National Academy of Sciences of the United States of America2010
A ratchet mechanism for amplification in low-frequency mammalian hearing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Effect of Contralateral Medial Olivocochlear Feedback on Perceptual Estimates of Cochlear Gain and Compression.Journal of the Association for Research in Otolaryngology : JARO · 2016Trial
- Article
- Attention to speech modulates distortion product otoacoustic emissions evoked by speech-derived stimuli in humans.Frontiers in neuroscience · 2026Article
- Hair cells in the cochlea must tune resonant modes to the edge of instability without destabilizing collective modes.bioRxiv : the preprint server for biology · 2024Article
- The cochlear ear horn: geometric origin of tonotopic variations in auditory signal processing.Scientific reports · 2020Article
- Unified cochlear model for low- and high-frequency mammalian hearing.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Unusual mechanical processing of sounds at the apex of the Guinea pig cochlea.Hearing research · 2018Article
- Static length changes of cochlear outer hair cells can tune low-frequency hearing.PLoS computational biology · 2018Article
- Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.Comprehensive Physiology · 2017Review
- Distortion-Product Otoacoustic Emission Measured Below 300 Hz in Normal-Hearing Human Subjects.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- Reticular lamina and basilar membrane vibrations in living mouse cochleae.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Minimal basilar membrane motion in low-frequency hearing.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A model of ionic transport and osmotic volume control in cochlear outer hair cells.Interface focus · 2014Article
- Effects of cochlear loading on the motility of active outer hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Waves on Reissner's membrane: a mechanism for the propagation of otoacoustic emissions from the cochlea.Cell reports · 2012Article
- Response to a pure tone in a nonlinear mechanical-electrical-acoustical model of the cochlea.Biophysical journal · 2012Article
- Article
- Auditory nerve excitation via a non-traveling wave mode of basilar membrane motion.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- Coupling active hair bundle mechanics, fast adaptation, and somatic motility in a cochlear model.Biophysical journal · 2011Article
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Authors and funding
2 authors.
Funding
Abstract
The sensitivity and frequency selectivity of hearing result from tuned amplification by an active process in the mechanoreceptive hair cells. In most vertebrates, the active process stems from the active motility of hair bundles. The mammalian cochlea exhibits an additional form of mechanical activity termed electromotility: its outer hair cells (OHCs) change length upon electrical stimulation. The relative contributions of these two mechanisms to the active process in the mammalian inner ear is the subject of intense current debate. Here, we show that active hair-bundle motility and electromotility can together implement an efficient mechanism for amplification that functions like a ratchet: Sound-evoked forces, acting on the basilar membrane, are transmitted to the hair bundles, whereas electromotility decouples active hair-bundle forces from the basilar membrane. This unidirectional coupling can extend the hearing range well below the resonant frequency of the basilar membrane. It thereby provides a concept for low-frequency hearing that accounts for a variety of unexplained experimental observations from the cochlear apex, including the shape and phase behavior of apical tuning curves, their lack of significant nonlinearities, and the shape changes of threshold tuning curves of auditory-nerve fibers along the cochlea. The ratchet mechanism constitutes a general design principle for implementing mechanical amplification in engineering applications.
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