ArticleThe Journal of cell biology2010
The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts.
Article in The Journal of cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Oligomerization and positive feedback on membrane recruitment encode dynamically stable PAR-3 asymmetries in thebioRxiv : the preprint server for biology · 2025Article
- From the Making of a Neural Lineage to the Making of a Tumor: Lessons from the "Simple" Drosophila Brain.Advances in experimental medicine and biology · 2025Review
- Positioning centrioles and centrosomes.The Journal of cell biology · 2024Review
- Live-Cell Imaging of Drosophila melanogaster Third Instar Larval Brains.Journal of visualized experiments : JoVE · 2023Article
- APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells.EMBO reports · 2023Article
- Parafibromin governs cell polarity and centrosome assembly in Drosophila neural stem cells.PLoS biology · 2022Article
- Asymmetric chromatin retention and nuclear envelopes separate chromosomes in fused cells in vivo.Communications biology · 2022Article
- Pericentrin interacts with Kinesin-1 to drive centriole motility.The Journal of cell biology · 2022Article
- Stem cells' centrosomes: How can organelles identified 130 years ago contribute to the future of regenerative medicine?World journal of stem cells · 2021Review
- Understanding microcephaly through the study of centrosome regulation in Drosophila neural stem cells.Biochemical Society transactions · 2020Review
- Going with the flow: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Dynamic centriolar localization of Polo and Centrobin in early mitosis primes centrosome asymmetry.PLoS biology · 2020Article
- Principles and mechanisms of asymmetric cell division.Development (Cambridge, England) · 2020Review
- Dynamic Polarization of Rab11a Modulates Crb2a Localization and Impacts Signaling to Regulate Retinal Neurogenesis.Frontiers in cell and developmental biology · 2020Article
- Article
- Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells.Developmental cell · 2019Article
- Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization.eLife · 2019Article
- A chemical-genetics approach to study the role of atypical Protein Kinase C inDevelopment (Cambridge, England) · 2019Article
- Article
- The last-born daughter cell contributes to division orientation of Drosophila larval neuroblasts.Nature communications · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms that maintain the orientation of cortical polarity and asymmetric division unchanged in consecutive mitoses in Drosophila melanogaster neuroblasts (NBs) are unknown. By studying the effect of transient microtubule depolymerization and centrosome mutant conditions, we have found that such orientation memory requires both the centrosome-organized interphase aster and centrosome-independent functions. We have also found that the span of such memory is limited to the last mitosis. Furthermore, the orientation of the NB axis of polarity can be reset to any angle with respect to the surrounding tissue and is, therefore, cell autonomous.
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