Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2010
Effects of bupropion on simulated demand for cigarettes and the subjective effects of smoking.
Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Experimental manipulations of behavioral economic demand for addictive commodities: a meta-analysis.Addiction (Abingdon, England) · 2020Pooled it
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2020Pooled it
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2014Pooled it
- Do lab-based assessments of pretreatment smoking reinforcement and cue-specific craving predict smoking cessation with varenicline?Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025Trial
- The Blinded-Dose Purchase Task: assessing hypothetical demand based on cocaine, methamphetamine, and alcohol administration.Psychopharmacology · 2023Trial
- Effects of episodic future thinking on reinforcement pathology during smoking cessation treatment among individuals with substance use disorders.Psychopharmacology · 2022Trial
- Effects of varenicline versus transdermal nicotine replacement therapy on cigarette demand on quit day in individuals with substance use disorders.Psychopharmacology · 2017Trial
- The impact of pre-cessation varenicline on behavioral economic indices of smoking reinforcement.Addictive behaviors · 2014Trial
- Estimating demand for alternatives to cigarettes with online purchase tasks.American journal of health behavior · 2014Trial
- Effects of varenicline on abstinence and smoking reward following a programmed lapse.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Trial
- Incremental efficacy of adding bupropion to the nicotine patch for smoking cessation in smokers with a recent history of alcohol dependence: results from a randomized, double-blind, placebo-controlled study.Drug and alcohol dependence · 2011Trial
- Using Behavioral Economics to Inform Behavior Analyst Regulation Fees in Ontario.Behavior analysis in practice · 2025Article
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2023Review
- Behavioral economic measurement of cigarette demand: A descriptive review of published approaches to the cigarette purchase task.Experimental and clinical psychopharmacology · 2020Review
- Using the Cigarette Purchase Task to examine the relative reinforcing value of cigarettes among mothers with versus without opioid dependence.Experimental and clinical psychopharmacology · 2020Article
- Comparing participant estimated demand intensity on the cigarette Purchase Task to consumption when usual-brand cigarettes were provided free.Preventive medicine · 2020Article
- Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations.Preventive medicine · 2020Article
- Behavioral economic demand as a unifying language for addiction science: Promoting collaboration and integration of animal and human models.Experimental and clinical psychopharmacology · 2020Review
- The impact of vaping and regulatory environment on cigarette demand: behavioral economic perspective across four countries.Addiction (Abingdon, England) · 2019Article
- A Behavioral Economic Analysis of Demand for Texting while Driving.The Psychological record · 2019Article
Corrections and comments
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2 authors.
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Abstract
introductionThe biobehavioral mechanism(s) mediating bupropion's efficacy are not well understood. Behavioral economic measures such as demand curves have proven useful in investigations of the reinforcing effects of drugs of abuse. Behavioral economic measures may also be used to measure the effect of pharmacotherapies on the reinforcing effects of drugs of abuse.
methodsThe effects of bupropion on simulated demand for cigarettes were investigated in a placebo-controlled double-blind clinical trial. Participants reported the number of cigarettes they would purchase and consume in a single day at a range of prices. The effects of medication on the subjective effects of smoking were also explored.
resultsDemand for cigarettes was well described by an exponential demand equation. Bupropion did not significantly decrease the maximum number of cigarettes that participants said they would smoke in a single day nor did it significantly alter the relation between price per cigarette and demand. Baseline demand elasticity did not predict smoking cessation, but changes in elasticity following 1 week of treatment did. Medication group had no effect on any subjective effects of smoking. DISCUSSION: Bupropion had no significant effects on demand for cigarettes. The exponential demand equation, recently introduced in behavioral economics, proved amenable to human simulated demand and might be usefully employed in other pharmacotherapy studies as it provides a potentially useful measure of changes in the essential value of the drug as a reinforcer. Such changes may be useful in predicting the efficacy of medications designed to reduce drug consumption.
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