ArticleThe American journal of psychiatry2010
Project among African-Americans to explore risks for schizophrenia (PAARTNERS): evidence for impairment and heritability of neurocognitive functioning in families of schizophrenia patients.
Article in The American journal of psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Meta-analysis of Face Perception in Schizophrenia Spectrum Disorders: Evidence for Differential Impairment in Emotion Face Perception.Schizophrenia bulletin · 2024Pooled it
- A meta-analysis of emotion perception and functional outcomes in schizophrenia.Schizophrenia research · 2012Pooled it
- Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors.International journal of geriatric psychiatry · 2013Trial
- The Philadelphia Neurodevelopmental Cohort: Perspective, Lessons, and Future Directions.Schizophrenia bulletin · 2025Article
- Genetic risk for schizophrenia and brain activation during the Penn Conditional Exclusion Test: A multiplex extended pedigree study.Journal of psychopathology and clinical science · 2025Article
- Validation of the cognitive section of the Penn computerized adaptive test for neurocognitive and clinical psychopathology assessment (CAT-CCNB).Brain and cognition · 2024Article
- Genetic Influences on Cognitive Dysfunction in Schizophrenia.Current topics in behavioral neurosciences · 2023Article
- MICEmi: A method to identify cognitive endophenotypes of mental illnesses.European psychiatry : the journal of the Association of European Psychiatrists · 2022Review
- Heritability of quantitative autism spectrum traits in adults: A family-based study.Autism research : official journal of the International Society for Autism Research · 2021Article
- Characteristics of youth with reported family history of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort.Schizophrenia research · 2020Article
- Common Data Elements for National Institute of Mental Health-Funded Translational Early Psychosis Research.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Review
- Cognition and community functioning in schizophrenia: The nature of the relationship.Journal of abnormal psychology · 2018Article
- Functional neuroimaging effects of recently discovered genetic risk loci for schizophrenia and polygenic risk profile in five RDoC subdomains.Translational psychiatry · 2017Article
- Manual Dexterity in Schizophrenia-A Neglected Clinical Marker?Frontiers in psychiatry · 2017Article
- Sex differences in brain and behavior in adolescence: Findings from the Philadelphia Neurodevelopmental Cohort.Neuroscience and biobehavioral reviews · 2016Review
- Association between polygenic risk for schizophrenia, neurocognition and social cognition across development.Translational psychiatry · 2016Article
- Performance of Verbal Fluency as an Endophenotype in Patients with Familial versus Sporadic Schizophrenia and Their Parents.Scientific reports · 2016Article
- The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth.NeuroImage · 2016Article
- Psychiatric genetics in China: achievements and challenges.Molecular psychiatry · 2016Article
- Social cognition as an RDoC domain.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveNeurocognitive impairments in schizophrenia are well replicated and widely regarded as candidate endophenotypes that may facilitate understanding of schizophrenia genetics and pathophysiology. The Project Among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) aims to identify genes underlying liability to schizophrenia. The unprecedented size of its study group (N=1,872), made possible through use of a computerized neurocognitive battery, can help further investigation of the genetics of neurocognition. The current analysis evaluated two characteristics not fully addressed in prior research: 1) heritability of neurocognition in African American families and 2) relationship between neurocognition and psychopathology in families of African American probands with schizophrenia or schizoaffective disorder.
methodAcross eight data collection sites, patients with schizophrenia or schizoaffective disorder (N=610), their biological relatives (N=928), and community comparison subjects (N=334) completed a standardized diagnostic evaluation and the computerized neurocognitive battery. Performance accuracy and response time (speed) were measured separately for 10 neurocognitive domains.
resultsThe patients with schizophrenia or schizoaffective disorder exhibited less accuracy and speed in most neurocognitive domains than their relatives both with and without other psychiatric disorders, who in turn were more impaired than comparison subjects in most domains. Estimated trait heritability after inclusion of the mean effect of diagnostic status, age, and sex revealed significant heritabilities for most neurocognitive domains, with the highest for accuracy of abstraction/flexibility, verbal memory, face memory, spatial processing, and emotion processing and for speed of attention.
conclusionNeurocognitive functions in African American families are heritable and associated with schizophrenia. They show potential for gene-mapping studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.