ArticleGenes & development2010
Personal genome sequencing: current approaches and challenges.
Article in Genes & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed.
- Candidate Genes, Markers, Signatures of Selection, and Quantitative Trait Loci (QTLs) and Their Association with Economic Traits in Livestock: Genomic Insights and Selection.International journal of molecular sciences · 2025Review
- The Evolution and Role of Molecular Tools in Measuring Diversity and Genomic Selection in Livestock Populations (Traditional and Up-to-Date Insights): A Comprehensive Exploration.Veterinary sciences · 2024Review
- DNA Enrichment Methods for Microbial Symbionts in Marine Bivalves.Microorganisms · 2022Article
- Discovery of genomic variation across a generation.Human molecular genetics · 2021Article
- Ecology and Evolution of Marine Fungi With Their Adaptation to Climate Change.Frontiers in microbiology · 2021Review
- Whole-genome sequencing of Tarim red deer (Frontiers in zoology · 2020Article
- GRAM: A GeneRAlized Model to predict the molecular effect of a non-coding variant in a cell-type specific manner.PLoS genetics · 2019Article
- Computational detection and experimental validation of segmental duplications and associated copy number variations in water buffalo ( Bubalus bubalis ).Functional & integrative genomics · 2019Article
- Longitudinal personal DNA methylome dynamics in a human with a chronic condition.Nature medicine · 2018Article
- Extracting Complementary Insights from Molecular Phenotypes for Prioritization of Disease-Associated Mutations.Current opinion in systems biology · 2018Article
- Existing and novel biomarkers for precision medicine in systemic sclerosis.Nature reviews. Rheumatology · 2018Review
- Studying microbial functionality within the gut ecosystem by systems biology.Genes & nutrition · 2018Review
- XCAVATOR: accurate detection and genotyping of copy number variants from second and third generation whole-genome sequencing experiments.BMC genomics · 2017Article
- Novel Biomarkers in the Diagnosis of Chronic Kidney Disease and the Prediction of Its Outcome.International journal of molecular sciences · 2017Review
- Mathematical and Computational Modeling in Complex Biological Systems.BioMed research international · 2017Review
- PiggyBac transposon-based polyadenylation-signal trap for genome-wide mutagenesis in mice.Scientific reports · 2016Article
- Diversity and population-genetic properties of copy number variations and multicopy genes in cattle.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis.American journal of nuclear medicine and molecular imaging · 2016Article
- Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing.BMC genomics · 2015Article
- Diverse array-designed modes of combination therapies in Fangjiomics.Acta pharmacologica Sinica · 2015Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The revolution in DNA sequencing technologies has now made it feasible to determine the genome sequences of many individuals; i.e., "personal genomes." Genome sequences of cells and tissues from both normal and disease states have been determined. Using current approaches, whole human genome sequences are not typically assembled and determined de novo, but, instead, variations relative to a reference sequence are identified. We discuss the current state of personal genome sequencing, the main steps involved in determining a genome sequence (i.e., identifying single-nucleotide polymorphisms [SNPs] and structural variations [SVs], assembling new sequences, and phasing haplotypes), and the challenges and performance metrics for evaluating the accuracy of the reconstruction. Finally, we consider the possible individual and societal benefits of personal genome sequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.