ArticleMolecular biology and evolution2010
Gene family size conservation is a good indicator of evolutionary rates.
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Comprehensive Analysis ofGenes · 2022Article
- Widespread false gene gains caused by duplication errors in genome assemblies.Genome biology · 2022Article
- Parallel Evolution of C-Type Lectin Domain Gene Family Sizes in Insect-Vectored Nematodes.Frontiers in plant science · 2022Article
- Article
- Congruence Amidst Discordance between Sequence and Protein-Content Based Phylogenies of Fungi.Journal of fungi (Basel, Switzerland) · 2020Article
- Global Evolutionary Analysis of 11 Gene Families Part of Reactive Oxygen Species (ROS) Gene Network in FourAntioxidants (Basel, Switzerland) · 2020Article
- Genomic Survey of Tyrosine Kinases Repertoire inEvolutionary bioinformatics online · 2020Article
- Comparative Genomic Analysis of the Pheromone Receptor Class 1 Family (V1R) Reveals Extreme Complexity in Mouse Lemurs (Genus, Microcebus) and a Chromosomal Hotspot across Mammals.Genome biology and evolution · 2020Article
- Evolution of salivary glue genes in Drosophila species.BMC evolutionary biology · 2019Article
- Article
- Genotyping and Bio-Sensing Chemosensory Proteins in Insects.Sensors (Basel, Switzerland) · 2017Review
- Whole Genome Duplications Shaped the Receptor Tyrosine Kinase Repertoire of Jawed Vertebrates.Genome biology and evolution · 2016Article
- Purifying selection shapes the coincident SNP distribution of primate coding sequences.Scientific reports · 2016Article
- Evolution and divergence of SBP-box genes in land plants.BMC genomics · 2015Article
- Genome-wide analysis reveals diverged patterns of codon bias, gene expression, and rates of sequence evolution in picea gene families.Genome biology and evolution · 2015Article
- Impacts of pretranscriptional DNA methylation, transcriptional transcription factor, and posttranscriptional microRNA regulations on protein evolutionary rate.Genome biology and evolution · 2014Article
- DNA methylation and evolution of duplicate genes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The impact of trans-regulation on the evolutionary rates of metazoan proteins.Nucleic acids research · 2013Article
- Comparative genomics of chemosensory protein genes reveals rapid evolution and positive selection in ant-specific duplicates.Heredity · 2013Article
- Position-dependent correlations between DNA methylation and the evolutionary rates of mammalian coding exons.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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Authors and funding
4 authors.
Funding
Abstract
The evolution of duplicate genes has been a topic of broad interest. Here, we propose that the conservation of gene family size is a good indicator of the rate of sequence evolution and some other biological properties. By comparing the human-chimpanzee-macaque orthologous gene families with and without family size conservation, we demonstrate that genes with family size conservation evolve more slowly than those without family size conservation. Our results further demonstrate that both family expansion and contraction events may accelerate gene evolution, resulting in elevated evolutionary rates in the genes without family size conservation. In addition, we show that the duplicate genes with family size conservation evolve significantly more slowly than those without family size conservation. Interestingly, the median evolutionary rate of singletons falls in between those of the above two types of duplicate gene families. Our results thus suggest that the controversy on whether duplicate genes evolve more slowly than singletons can be resolved when family size conservation is taken into consideration. Furthermore, we also observe that duplicate genes with family size conservation have the highest level of gene expression/expression breadth, the highest proportion of essential genes, and the lowest gene compactness, followed by singletons and then by duplicate genes without family size conservation. Such a trend accords well with our observations of evolutionary rates. Our results thus point to the importance of family size conservation in the evolution of duplicate genes.
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