ArticleHypertension (Dallas, Tex. : 1979)2010
Erythropoietin increases expression and function of vascular copper- and zinc-containing superoxide dismutase.
Article in Hypertension (Dallas, Tex. : 1979), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Inactivation of BACE1 increases expression of endothelial nitric oxide synthase in cerebrovascular endothelium.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Role of superoxide ion formation in hypothermia/rewarming induced contractile dysfunction in cardiomyocytes.Cryobiology · 2018Article
- Antioxidant and antiapoptotic effects of darbepoetin-α against traumatic brain injury in rats.Archives of medical science : AMS · 2015Article
- Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice.Journal of neurochemistry · 2015Article
- Erythropoietin prevents endothelial dysfunction in GTP-cyclohydrolase I-deficient hph1 mice.Journal of cardiovascular pharmacology · 2014Article
- Erythropoietin increases bioavailability of tetrahydrobiopterin and protects cerebral microvasculature against oxidative stress induced by eNOS uncoupling.Journal of neurochemistry · 2014Article
- Increased production of superoxide anion contributes to dysfunction of the arteriovenous fistula.American journal of physiology. Renal physiology · 2012Article
- PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice.Brain research · 2012Article
- Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice.Journal of neurochemistry · 2012Article
- Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice.Diabetes · 2012Article
- Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.American journal of physiology. Heart and circulatory physiology · 2011Article
- Protecting against vascular disease in brain.American journal of physiology. Heart and circulatory physiology · 2011Review
- Cardiovascular effects of erythropoietin an update.Advances in pharmacology (San Diego, Calif.) · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have shown that treatment with erythropoietin (EPO) exerts vascular protective effects. The exact mechanisms responsible for these effects are not completely understood. In the present study, we hypothesized that EPO stimulates expression and activity of copper- and zinc-containing superoxide dismutase (SOD1), thus protecting vascular tissue from oxidative stress induced by excessive concentrations of superoxide anions. EPO treatment of wild-type mice for 2 weeks (1000 U/kg, SC, biweekly) significantly increased aortic expression of SOD1. This effect resulted in a significant reduction of superoxide anion concentrations in aorta of treated mice. The ability of EPO to reduce vascular production of superoxide anions was abolished in SOD1-deficient mice. In a mouse model of wire-induced injury of the common carotid artery, treatment of wild-type mice with EPO prevented pathological remodeling, whereas the vascular effect of EPO was absent in SOD1-deficient mice. Our findings demonstrate that treatment with EPO increases vascular expression of SOD1. This effect appears to be an important molecular mechanism underlying vascular protection by EPO.
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