ArticleDevelopmental biology2010
TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- Gas1 regulates embryonic tongue muscle proliferation, differentiation and maturation via alternative pathways to Hedgehog signaling.Development (Cambridge, England) · 2025Article
- Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme.Development (Cambridge, England) · 2023Article
- The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis.Development (Cambridge, England) · 2022Article
- Gene profiling in dorso-ventral patterning of mouse tongue development.Genes & genomics · 2022Article
- Deletion of Nf2 in neural crest-derived tongue mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region- and stage-specific manner.Cell proliferation · 2021Article
- Augmented BMP4 signal impairs tongue myogenesis.Journal of molecular histology · 2021Article
- Tissue-specific analysis of Fgf18 gene function in palate development.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis.eLife · 2021Article
- Orofacial Muscles: Embryonic Development and Regeneration after Injury.Journal of dental research · 2020Review
- Regulatory Mechanisms of Soft Palate Development and Malformations.Journal of dental research · 2019Review
- Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Article
- Connecting muscle development, birth defects, and evolution: An essential role for muscle connective tissue.Current topics in developmental biology · 2019Review
- Article
- Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development.Frontiers in genetics · 2018Review
- The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development.Development (Cambridge, England) · 2017Article
- A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development.The Journal of biological chemistry · 2017Article
- Cilia-dependent GLI processing in neural crest cells is required for tongue development.Developmental biology · 2017Article
- Multiple Cranial Organ Defects after Conditionally Knocking OutFrontiers in physiology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Skeletal muscles are formed from two cell lineages, myogenic and fibroblastic. Mesoderm-derived myogenic progenitors form muscle cells whereas fibroblastic cells give rise to the supportive connective tissue of skeletal muscles, such as the tendons and perimysium. It remains unknown how myogenic and fibroblastic cell-cell interactions affect cell fate determination and the organization of skeletal muscle. In the present study, we investigated the functional significance of cell-cell interactions in regulating skeletal muscle development. Our study shows that cranial neural crest (CNC) cells give rise to the fibroblastic cells of the tongue skeletal muscle in mice. Loss of Tgfbr2 in CNC cells (Wnt1-Cre;Tgfbr2(flox/flox)) results in microglossia with reduced Scleraxis and Fgf10 expression as well as decreased myogenic cell proliferation, reduced cell number and disorganized tongue muscles. Furthermore, TGF-beta2 beads induced the expression of Scleraxis in tongue explant cultures. The addition of FGF10 rescued the muscle cell number in Wnt1-Cre;Tgfbr2(flox/flox) mice. Thus, TGF-beta induced FGF10 signaling has a critical function in regulating tissue-tissue interaction during tongue skeletal muscle development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.