ReviewBiochimica et biophysica acta2010
F1F0-ATP synthases of alkaliphilic bacteria: lessons from their adaptations.
Review in Biochimica et biophysica acta, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 93 citations in OpenAlex.
- Time-resolved transcriptomics reveals mechanisms of acute and sustained low-pH adaptation inSynthetic and systems biotechnology · 2026Article
- ATP synthase activity boosts membrane proton acceptance and lateral diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- HFrontiers in microbiology · 2025Review
- Saline-Alkali Soil Property Improved by the Synergistic Effects ofInternational journal of molecular sciences · 2023Article
- Soil conditions and the plant microbiome boost the accumulation of monoterpenes in the fruit of Citrus reticulata 'Chachi'.Microbiome · 2023Article
- An examination of protist diversity in serpentinization-hosted ecosystems of the Samail Ophiolite of Oman.Frontiers in microbiology · 2023Article
- Insights into the physiological and genomic characterization of three bacterial isolates from a highly alkaline, terrestrial serpentinizing system.Frontiers in microbiology · 2023Article
- Metabolic challenges and key players in serpentinite-hosted microbial ecosystems.Frontiers in microbiology · 2023Review
- Transcriptomic responses of haloalkalitolerant bacterium Egicoccus halophilus EGI 80432Extremophiles : life under extreme conditions · 2021Article
- Highly integrated adaptive mechanisms in Spiribacter halalkaliphilus, a bacterium abundant in Chinese soda-saline lakes.Environmental microbiology · 2021Article
- Comparative genome analysis of3 Biotech · 2021Article
- Contribution of the Locus of Heat Resistance to Growth and Survival ofMicroorganisms · 2021Article
- Analysis of the Complete Genome of the Alkaliphilic and Phototrophic FirmicuteMicroorganisms · 2020Article
- Why Nature Chose Potassium.Journal of molecular evolution · 2019Review
- Recent advances of pH homeostasis mechanisms in Corynebacterium glutamicum.World journal of microbiology & biotechnology · 2019Review
- Draft Genome Sequence of Alkalicoccus saliphilus DSM 15402Microbiology resource announcements · 2019Article
- Optimization of ATP Synthase c-Rings for Oxygenic Photosynthesis.Frontiers in plant science · 2019Article
- Convergent evolution of unusual complex I homologs with increased proton pumping capacity: energetic and ecological implications.The ISME journal · 2018Article
- Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery.Pathogens (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
This review focuses on the ATP synthases of alkaliphilic bacteria and, in particular, those that successfully overcome the bioenergetic challenges of achieving robust H+-coupled ATP synthesis at external pH values>10. At such pH values the protonmotive force, which is posited to provide the energetic driving force for ATP synthesis, is too low to account for the ATP synthesis observed. The protonmotive force is lowered at a very high pH by the need to maintain a cytoplasmic pH well below the pH outside, which results in an energetically adverse pH gradient. Several anticipated solutions to this bioenergetic conundrum have been ruled out. Although the transmembrane sodium motive force is high under alkaline conditions, respiratory alkaliphilic bacteria do not use Na+- instead of H+-coupled ATP synthases. Nor do they offset the adverse pH gradient with a compensatory increase in the transmembrane electrical potential component of the protonmotive force. Moreover, studies of ATP synthase rotors indicate that alkaliphiles cannot fully resolve the energetic problem by using an ATP synthase with a large number of c-subunits in the synthase rotor ring. Increased attention now focuses on delocalized gradients near the membrane surface and H+ transfers to ATP synthases via membrane-associated microcircuits between the H+ pumping complexes and synthases. Microcircuits likely depend upon proximity of pumps and synthases, specific membrane properties and specific adaptations of the participating enzyme complexes. ATP synthesis in alkaliphiles depends upon alkaliphile-specific adaptations of the ATP synthase and there is also evidence for alkaliphile-specific adaptations of respiratory chain components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.