Evidence map›Paper›PMID 20193638›Full record

ReviewDiscovery medicine2010

Glioblastoma genetics: in rapid flux.

Benjamin W Purow, David Schiff

Abstract readReview
In one paragraph

Review in Discovery medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells.Analytical cellular pathology (Amsterdam) · 2020
    Review
  3. Article
  4. Review
  5. The Multifaceted Metabolism of Glioblastoma.Advances in experimental medicine and biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Benjamin W PurowNeuro-Oncology Center, Department of Neurology, University of Virginia, Charlottesville, Virginia 22908, USA. bwp5g@hscmail.mcc.virginia.edu
David Schiff

Funding

Investigating Alpha-secretase inhibitors as Notch inhibitors & anti-glioma agentsR01CA134768 · NCI · UNIVERSITY OF VIRGINIA · PI PUROW, BENJAMIN W. · 2008 to 2012
$1.3M
NCI NIH HHS R01 CA134768
6 · The paper itself

Abstract

Glioblastoma is the most common and most lethal primary brain tumor. While small progress has been made in treating this cancer in recent years, glioblastoma remains largely resistant to all existing therapies. It has been hoped that dissection of the genetics of this cancer would lead to more targeted and effective treatments, and new advances may finally be bringing this closer to fruition. Within the last few years, high-throughput efforts such as The Cancer Genome Atlas and a massive sequencing project have yielded novel insights and classifications of this dreaded cancer. The likely impact on care delivery in the clinic may only be a few years away. The rapid and exciting pace of advances in glioblastoma genetics has prompted this up-to-date review.

Indexed as

Antineoplastic AgentsBrain NeoplasmsEpigenesis, GeneticGenome, HumanGlioblastomaHumansMedical OncologyMicroRNAsModels, GeneticMutationPrognosisSyndromeAntineoplastic AgentsMicroRNAs

Identifiers

PMID20193638
PMCPMC3365574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.